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first_imgSAN DIEGO, CALIFORNIA—This past Wednesday, at a discussion titled “Stopping the Deadly Ebola Outbreak” held at the Scripps Research Institute here, a local TV reporter repeatedly prodded one of the star panelists, Kevin Whaley, the CEO of Mapp Biopharmaceutical of San Diego.After Whaley explained that he had no idea whether ZMapp, his company’s now famous experimental antibody cocktail used to treat Ebola victims, really worked, the journalist continued to press. “From what you’ve seen in your research—and what your heart says—what do you say?”The audience of 100 people or so broke into nervous giggles.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)“I’m not willing to speculate on that,” Whaley replied.The dogged reporter gave it one more try, referring to two American health workers who were infected with Ebola in Liberia, returned to the United States and received ZMapp, and lived to tell about it. “How happy were you to see the two missionaries walk out of the hospital?”“That was certainly very satisfying, and hopefully ZMapp played some role in that,” Whaley said. “But that remains to be seen.”The exchange highlights the growing hope that some biomedical intervention—such as a treatment like ZMapp—will allow more people to survive Ebola infections. Time and time again, however, hope and hype have become knotted together.Today, that knot is sure to grow tighter with the publication online in Nature of an encouraging monkey experiment with ZMapp, in which 100% of the infected monkeys survived. It is sure to further raise expectations of a cure—and further confuse the public about just how near a cure might be. Even the authors of the new study caution that extending the monkey results to humans could be a long and difficult task.The experiments, led by Gary Kobinger of the Public Health Agency of Canada in Winnipeg, first tested combinations of Ebola antibodies made by his lab and Mapp Bio to find a cocktail that worked best in guinea pigs and then monkeys. They selected the concoction now called ZMapp and gave it to three groups of six monkeys; all received intramuscular injections of high doses of Ebola virus. A control group of three monkeys were given dummy drugs.The treated monkeys each received a total of three doses of ZMapp, one every 3 days. Treatment began at 3 days postinfection for one group, at 4 days for another, and at 5 for a third. All 18 of the monkeys had evidence of infection, many became ill, and two nearly died.In the end, 100% of the treated monkeys survived, and 100% of the control animals quickly died. Although the experiment used an older Ebola virus that differs from the strain now in West Africa, the researchers showed in a test-tube study that ZMapp also worked against the more recently isolated virus.The results are “a monumental achievement,” wrote virologist Thomas Geisbert, who studies Ebola virus at the University of Texas Medical Branch at Galveston, in a Nature editorial accompanying the study.“It’s a great study,” Geisbert tells ScienceInsider. “I’ve got shelves and shelves and shelves of things that inhibit Ebola in cell culture and a small percent inhibit it in guinea pigs or mice. And I’ve got shelves and shelves of things that work in guinea pigs and mice but not in monkeys. If you save 100% of monkeys up to 5 days after infecting them, that’s a huge bar to clear.”In a teleconference held by Nature today, Kobinger said it was “quite remarkable” that they could rescue infected animals that had advanced disease, which he called “a very important step forward in the fight against Ebola virus.” But Kobinger also stressed that many unknowns remain about the differences between this monkey model and human infection.To begin with, most humans are infected by exposure to bodily fluids from people with Ebola, not by syringes that hold a huge bolus of virus injected into their muscles. This kills monkeys on average in 8 days, while it typically takes 3 to 21 days for humans to develop symptoms. “It’s very hard to translate” the disease progression in this monkey model to humans, Kobinger said. But a monkey infected by this route and left untreated for 5 days is 3 days away from death he said, which indicates that ZMapp worked well into the disease.The monkeys received three doses of ZMapp, and it sometimes required a second one before the level of Ebola virus in their blood—the viral load—dropped. With the seven treated humans, one person who died received only a single dose, and no one has yet reported how many doses the others received. Kobinger said he “would not expect” a single dose to work. “What the antibody is really doing is buying time,” said Kobinger, stressing the importance of proper medical care on survival.Kobinger said he had no idea whether the antibodies had any effect on viral load in these patients, as they were given the experimental ZMapp on a “compassionate use” basis. “When each of the clinicians or clinical teams that have been using ZMapp release their data, we’ll get a better sense of maybe the efficacy, but even then, it’s hard because it’s not really a designed study,” Kobinger said. “Unfortunately, it may be limited what we’re really going to learn from those seven patients.”In preliminary experiments not reported in the Nature paper, Korbinger said he has in vivo evidence that ZMapp works against the strain now circulating in West Africa. He said future experiments will analyze the impact of providing infected monkeys with effective intensive care. His group also wants to see how low of a dose of ZMapp they can give infected monkeys and still rescue them. “One of the things that is very urgent for us to do is a dose de-escalation study so that we can see what the minimum amount of antibody is so maybe with the same amount of material we could do more,” he said.The availability of ZMapp is a critical issue for the growing number of people who want access to it on a compassionate use basis. Mapp Bio says it now has no more ZMapp on hand. Kentucky BioProcessing in Owensboro grows the ZMapp antibodies in tobacco plants. In a 2012 press release, that company’s chief operating officer, Barry Bratcher, said it had a fully automated production system “that operates in accordance with good manufacturing practices” and could “generate a new antibody lot in two weeks to rapidly address new threats and new outbreaks.” Bratcher did not reply to an e-mail from ScienceInsider to discuss that prediction.At the Scripps panel talk, Whaley told ScienceInsider that they were still trying to sort out production issues. “Clearly we misstated [the production time needed],” Whaley said. “That clearly was not our intention.”Questions also have been raised about how it was decided to give ZMapp to the seven people who have received ZMapp so far, two of whom were from Europe and two from the United States. Whaley said the company responds to requests that come through the U.S. Food and Drug Administration and has no say in who ultimately had received the product.Two of the seven ZMapp patients have died. Their outcomes ultimately say nothing about the treatment: The people received the drug at different stages of disease, and four were evacuated to wealthy countries for top-notch care—likely the most important determinant of survival. No information has become public about the effect the antibodies had on their levels of virus. What’s more, it’s an experiment without a control. “These people did not have an identical twin who was infected the same day and didn’t get treated,” said Scripps structural biologist Erica Ollmann Saphire, who was a panelist at the event there and helped Mapp Bio select antibodies. “That’s why we need to do the human clinical trial.”Human studies of ZMapp are scheduled to begin in early 2015.Meanwhile, Ebola cases continue to rise. The World Health Organization as of yesterday reported 3069 cases and 1552 deaths, a case fatality rate of 52%. Senegal today reported its first case.*The Ebola Files: Given the current Ebola outbreak, unprecedented in terms of number of people killed and rapid geographic spread, Science and Science Translational Medicine have made a collection of research and news articles on the viral disease freely available to researchers and the general public.last_img read more

3 12 19

first_imgIn 1670, a Carthusian monk named Père Dom Anthelme discovered a “new star,” or nova, near the constellation Cygnus, pointing out to his fellow monks a star that did not appear on maps of the sky. Now, as astronomers report online today in Nature, this nova, CK Vulpeculae, had an unusual cause: The explosion probably occurred when two stars orbiting each other spiraled together and merged into one. New observations reveal molecules in the gas surrounding the merged star (white and yellow show the brightest glow at visible wavelengths; green contours indicate carbon monoxide gas). The molecules contain lots of isotopes that arise during nuclear reactions, so they likely spilled out of the stellar interiors when the stars joined together. Astronomers have recently discovered that rare “red novae”—named for their color—result when stars merge; now the aftermath of the 17th century nova indicates what such stellar mergers look like centuries later.last_img read more

22 11 19

first_imgPhoenix Suns guard Jevon Carter (4) drives on Sacramento Kings guard Cory Joseph during the second half during an NBA basketball game Wednesday, Oct. 23, 2019, in Phoenix. (AP Photo/Rick Scuteri)PHOENIX — Coach Monty Williams wanted Jevon Carter to slow down. The backup point guard didn’t pay attention.Two unexpected 3-pointers later, the Phoenix Suns had the spark they needed to blow past the Sacramento Kings for a 124-95 win in the season opener for both teams on Wednesday night.ADVERTISEMENT Matteo Guidicelli had saved up for Sarah G’s ring since 2014? MOST READ Read Next Don’t miss out on the latest news and information. This jewelry designer is also an architect UP NEXTKings: Host Portland on Friday.Suns: Visit Denver on Friday.Sports Related Videospowered by AdSparc Doncic-Porzingis debut leads Mavericks past Wizards Someone from the Philippines could win a $208 million jackpot this week! Duterte calls himself, Go, Cayetano ‘the brightest stars’ in PH politics Canadian vaping study details danger from ‘popcorn lung’ chemicalcenter_img “Jevon just doesn’t listen to me, that’s pretty much it,” Williams said with a grin. “He just goes nuts, hits shots and defensively he gets all over people. He has selective hearing. I was trying to scream to him to slow down, but he’s a pitbull. That’s what I love about him.”While the reserves stepped up, the starters played well, too.FEATURED STORIESSPORTSGreatest ever?SPORTSFormer PBA import Anthony Grundy passes away at 40SPORTSSan Miguel suspends Santos, Nabong, Tubid indefinitely after ‘tussle’ in practiceDevin Booker had 22 points and 10 assists, and Kelly Oubre Jr. added 21 points. Veteran guard Ricky Rubio had 11 points, 11 assists, six rebounds and four steals in his first game after signing a three-year deal worth $51 million.It was an encouraging night for a franchise that hasn’t been to the playoffs since 2010 and finished with a dismal 19-63 record last season. Sports venues to be ready in time for SEA Games PLAY LIST 00:59Sports venues to be ready in time for SEA Games01:27Filipino athletes get grand send-off ahead of SEA Games00:50Trending Articles02:11Makabayan bloc defends protesting workers, tells Año to ‘shut up’03:07PH billiards team upbeat about gold medal chances in SEA Games01:38‘Bato’ to be ‘most effective’ CHR head? It’s for public to decide – Gascon02:07Aquino to Filipinos: Stand up vs abuses before you suffer De Lima’s ordeal01:28Ex-President Noynoy Aquino admits contracting pneumonia00:45Aquino agrees with Drilon on SEA games ‘kaldero’ spending issue “We have a lot of potential, but it’s just one game,” Rubio said. “We have to show it every night. Tomorrow we come back, go to practice and get better.”Deandre Ayton, the No. 1 pick one year ago, added 18 points and 11 rebounds while shooting 9 of 14 from the field.Sacramento was led by Buddy Hield, who scored 22 of his 28 points in the first half. Hield shot 10 of 19 from the field, including 6 of 12 from 3-point range. Marvin Bagley III added 14 points and 10 rebounds.The Kings shot just 28 percent from the field and had 18 turnovers in the second half.“They had the momentum, they made shots, they made plays, they played harder than us,” Hield said. “They deserved to win.”ADVERTISEMENT Williams won in his Suns coaching debut. The 48-year-old Williams coached the New Orleans Hornets for five seasons from 2010-15 and got another opportunity with Phoenix during the offseason.The Suns trailed by five at halftime but rallied for an 86-76 advantage headed into the fourth. Carter hit back-to-back 3-pointers late in the third to give the Suns some unexpected offense, highlighting an impressive run by the Suns’ second unit.Carter finished with 11 points, including three 3-pointers. Tyler Johnson added 10 points in 17 minutes.“We just go out there, play hard and play together,” Carter said. “Sometimes it’s going to work. Sometimes it’s not. But I feel more times than not it’s going to work.”EMOTIONAL NIGHTWilliams also won as a head coach for the first time without his wife Ingrid, who died in a car accident in 2016 at 44 years old.“First time I’ve done this without Ingrid and that was just different,” Williams said. “A lot of emotions, a lot of good stuff. So thankful my kids were there tonight for the whole game and got to see that. So glad I got to do that with this group.”TIP-INSKings: F Harry Giles III (sore left knee) was held out. … The game was the Kings debut of coach Luke Walton. The 39-year-old coached the Lakers for three seasons before being fired during the past offseason. … One of Walton’s assistants is Igor Kokoskov, who coached the Suns last season before getting fired after just one year.Suns: Rookie guards Ty Jerome (right ankle sprain) and Cameron Johnson (left calf soreness) were inactive. … Booker was called for a technical foul in the third quarter after arguing with a referee. … The Suns improved to 36-17 all-time in home openers. Becoming his own man DTI creates Marahuyo, a luxe Filipino fashion brand for global buyers Ethel Booba on SEA Games cauldron: ‘Sulit kung corrupt ang panggatong’ LATEST STORIES View commentslast_img read more

21 11 19

first_imgThe current R&J certification system was also discussed The current R&J certification system was also discussed in the meetings, which concluded yesterday. “The current 5-star R&J programme will be disbanded and there will be greater empowerment and efficiency brought to the role of the R&J evaluators during competitions,” the AIBA said. “It was also recommended that the Draw of the R&Js for each bout will now be automated via our supplier Swiss Timing, and no longer conducted by a three-person Draw Commission to instill greater transparency.” The AIBA, however, maintained that the sports integrity remains intact despite allegations to the contrary. The body threatened action against boxers, who display “inappropriate” behaviour after losses. “As a governing body, AIBA will always seek to evolve the sport but will continue to refute unsubstantiated claims that have tarnished the reputation of our sport,” it said. “The judging system can never become a scapegoat for boxers and coaches who perform disappointingly in the ring and display inappropriate behaviour or comments to media. This will be even more closely monitored in the future and firm disciplinary action will be taken when necessary.” Following the Commissions recommendations, all relevant ratifications of current AIBA statutes and bye-laws to incorporate the decisions outlined above will be made at the Extraordinary Congress which will be held in December. PTI PM CM CMlast_img read more

18 11 19

first_imgNEW YORK (AP) — Joel Embiid had 31 points and 16 rebounds, and passed to Mike Scott for the go-ahead 3-pointer with 18 seconds left as the Philadelphia 76ers beat the Brooklyn Nets 112-108 on Saturday to take a 3-1 series lead.Embiid also had a flagrant foul that led to a scuffle and two ejections during an eventful return to the lineup after missing Game 3 with a sore left knee.Tobias Harris had 24 points, eight rebounds and six assists for the 76ers. They can advance to the Eastern Conference semifinals for the second straight season with a victory at home Tuesday night.They got a big boost from the return of Embiid, who scored eight straight points in the fourth quarter after the Nets led by seven. He helped the 76ers overcome the loss of Jimmy Butler, who was ejected in the third quarter after Embiid’s hard foul on Jarrett Allen.Caris LeVert scored 25 points after being inserted into the Nets’ starting lineup. D’Angelo Russell and Allen each added 21.Jared Dudley also was inserted into the starting lineup for the Nets and had been agitating the 76ers with his defense and his talking, but was gone midway through the third quarter as one of the central figures in the scuffle that spilled into the stands.Embiid swung his arm forcefully while fouling Allen, and Dudley quickly moved in and bumped Embiid. Butler then ran in and pushed Dudley to start the shoving. Dudley, Simmons and referee Ed Malloy all got knocked into the seats, and after a lengthy video review, Butler and Dudley were given technical fouls and ejected, and Embiid’s foul was ruled a flagrant 1.Embiid would later make the biggest mark with his offense. The 76ers were trying to get the ball to him trailing by one after Joe Harris’ layup, but Embiid couldn’t control the pass under the rim. But he regained the ball and found Scott in the corner for a 3 and a 110-108 lead.Allen then turned the ball over after three Sixers surrounded him and Harris closed out the scoring with two free throws.NUGGETS 107, SPURS 103SAN ANTONIO (AP) — Nikola Jokic had 29 points and 12 rebounds, Jamal Murray added 24 points and Denver beat San Antonio, rebounding from a flat performance tie the series at two games apiece.Denver Nuggets center Nikola Jokic (15) scores past San Antonio Spurs center LaMarcus Aldridge (12) during the first half of Game 4 of an NBA basketball playoff series in San Antonio, Saturday, April 20, 2019. (AP Photo/Eric Gay)LaMarcus Aldridge had 24 points and nine rebounds for San Antonio. DeMar DeRozan added 19 points before he was ejected with five minutes remaining after arguing with an official over an offensive foul.Game 5 is Tuesday night in Denver.ROCKETS 104, JAZZ 101SALT LAKE CITY (AP) — James Harden overcome a horrible shooting performance and scored 14 of his 22 points in the fourth quarter, leading the Houston past Utah for a commanding 3-0 lead in their first-round playoff series.Harden made a 3-pointer and added two free throws with 42.4 seconds left to give the Rockets a 101-97 lead. After Donovan Mitchell made two free throws, Harden missed another 3-point attempt, but P.J. Tucker, who finished with 12 points and 10 rebounds, grabbed the rebound, was fouled and made one of two free throws.Mitchell had a wide-open look at a 3-pointer on the ensuing possession, but like so many of his shots in the hard-fought contest, it was off the mark.Harden misfired on his first 15 shots and was 3-for-20 shooting with 10 assists. He was 14 for 16 from the line.Chris Paul scored 18 points and Clint Capela had 11 points and 14 rebounds for the Rockets, who won despite shooting 38.4 percent from the field and 67.6 percent from the line.Mitchell scored 34 points but struggled shooting, too, making just 9 of his 27 attempts. Derrick Favors had 13 for the Jazz.Game 4 is Monday night in Utah.___TweetPinShare0 Shareslast_img read more

17 11 19

first_imgNew Delhi, Nov 21 (PTI) Accusing Madhya Pradesh Congress president Kamal Nath of seeking votes on religious grounds, the BJP Wednesday urged the Election Commission to take action against him and his party. The party also accused him of hatching a “criminal conspiracy against free and fair polls” in the state, as it in its complaint to the EC referred to a purported video in which Kamal Nath is allegedly asking a group of Muslims to ensure that the Congress gets 90 per cent of votes in their booths.The Congress will suffer badly in the November 28 polls in the state if it does not happen, Kamal Nath, who has so far not responded to the charge, allegedly said.A BJP delegation, including Union ministers Mukhtar Abbas Naqvi and S S Ahluwalia besides Rajya Sabha member and party spokesperson Anil Baluni, submitted a memorandum to the commission in which the party also sought action against a news channel over “paid opinion polls”.There has been no official response from the Congress.”This is a case of Congress spicing up its secularism with communalism. It sports a ’tilak’ on the road and wears a cap in private,” Naqvi said, in an apparent dig at the opposition party over its Hindu outreach and Kamal Nath’s alleged appeal to Muslims for their votes at a private meeting.It is a clear case of communal appeal for votes, he said.The BJP urged the EC to take action against Kamal Nath and the Congress under the Representation of People Act, which bars seeking votes in the name of religion.advertisementThe Congress leader had termed as fake another video in which he was purportedly seen urging Muslims to be wary of the RSS agenda.The Congress is a “history-sheeter” in communal politics, Naqvi alleged.The BJP leader also claimed that an opinion poll broadcast by a news channel on November 18 violated the EC’s guidelines that bar telecast of any opinion or exit poll until the last day of poling is over after the Model Code of Conduct comes into effectThe survey had forecast a better show by the Congress than the BJP in the assembly polls and Naqvi alleged it was a case of “paid news”.The BJP has also sought action against the Congress for allegedly offering allurements to voters in Madhya Pradesh. PTI KR GVSlast_img read more

16 11 19

first_imgLeague Two Share on LinkedIn Read more Carbon offsetting Share on WhatsApp Forest Green Rovers Share on Facebook Share on Twitter Share via Email A British professional football club that is powered by renewable energy and serves vegan food to players, staff and fans has received a prestigious United Nations certification.Forest Green Rovers, which plays in League Two, announced on Monday that it has become the world’s first UN certified carbon-neutral football club.Based in the Gloucestershire town of Nailsworth, the club has signed up for a United Nations Framework Convention on Climate Change (UNFCCC) initiative called Climate Neutral Now for the 2018-19 season.FGR’s green credentials have been attracting attention around the world for several years. It claims to be the first vegan football club in the world after receiving the vegan trademark from the Vegan Society.The club says it became vegan because of the “huge environmental and animal welfare impacts of livestock farming”, as well as to improve player performance and give fans healthier, tastier food on match days. Topics news FGR is powered by 100% green energy from Ecotricity – the company founded by the club’s chairman, Dale Vince – some of which is generated by the solar panels on the stadium roof.The team plays on an organic pitch, which is cut by a solar-powered robot lawnmower, and all rainwater that falls on the stands or on the pitch is recycled to minimise the club’s use of mains water.FGR has electric car charging facilities at the stadium, to encourage fans to travel to games sustainably.FGR was promoted to the Football League for the first time in the club’s 129-year history last year and will start its second season in League Two – the fourth tier of professional football in England – next month. Climate change Sign up to the Green Light email to get the planet’s most important stories Share on Pinterest Greenhouse gas emissions Share on Messenger Reuse this contentlast_img read more

20 10 19

first_imgOsaka: Prime Minister Narendra Modi Thursday held wide-ranging talks with his Japanese counterpart Shinzo Abe on the global economy, issues of fugitive economic offenders and disaster management and announced that the Indian President will participate in the coronation ceremony of Emperor Naruhito in October. It was the first meeting between the two leaders since the start of Japan’s Reiwa era and Modi’s re-election after the general polls. Modi thanked Abe for his warm welcome to him and the Indian delegation visiting Japan for the G20 Summit. He also appreciated Japan’s leadership as the G20 chairman. Also Read – Ahead of Xi’s visit, China says Kashmir issue should be resolved bilaterally; drops UN referencesThe prime minister said that President Ram Nath Kovind will participate in the coronation ceremony of Emperor Naruhito in October. The prime minister congratulated Abe and Japan’s citizens for the start of the Reiwa era. The term for the new era is made up of the two characters Rei and Wa. Rei means “commands” or “order”, as well as “auspicious” or “good”. Wa means “harmony”, and is also used in the Japanese word for “peace”. Prime Minister Modi said that he was looking forward to the visit of Abe to India later this year for the Annual Summit. Also Read – Rajnath Singh arrives for Rafale handover ceremony in FranceLater, briefing media, Foreign Secretary Vijay Gokhale said it was a “warm” meeting the two prime ministers who are “old friends” and they had a “very constructive and detailed discussion” on the bilateral relationship. “Abe initially began the discussion with his expectation from the G20 Summit. They spoke about the importance of focussing on the global economy,” Gokhale said. Abe referred to the PM Modi’s initiatives on the earlier G20 meetings on the issue of fugitive economic offenders and he said the G20 should deal with this problem as part of its anti-corruption measures. Abe also underlined the need to find appropriate measures to check the global trade issues and data flows and underlined that the G20 should also come up with a constructive message on the issue of climate change. “These are the areas where Abe hoped that he would get the understanding and support of the G20 members, including that of India,” Gokhale said. PM Abe also referred to his forthcoming visit to India for the Annual Bilateral Summit.last_img read more

13 10 19

first_imgDETROIT — Chris Reynolds was promoted by Toyota late last year to one of the toughest jobs in the U.S. auto industry. He’s in charge of North American manufacturing, as well as human resources, legal, finance and communications.It’s manufacturing that will present the biggest challenge for Reynolds, who must navigate uncertain U.S. trade policies including tariff threats and possible replacement of the North American Free Trade Agreement with Canada and Mexico. Toyota produces vehicles in both countries for sale in the U.S.Also, U.S. auto sales are expected to decline slightly in 2019, and sales of traditional sedans, once staples in Toyota’s U.S. model lineup, are falling.Reynolds, the son of a Ford factory worker who grew up in Detroit, spoke with The Associated Press after his duties were expanded by the company. The interview has been edited for length and clarity.Q: The U.S.-Mexico-Canada Agreement, which replaces the North American Free Trade Agreement, is still up in the air. Twenty-five per cent tariffs on imported vehicles and parts also are on the table. How does the new agreement affect Toyota, and would you be able to bring production from Japan to Alabama or some other U.S. plant if tariffs go into effect?A: We think that the recently negotiated USMCA, if it’s approved, and we’re optimistic that it will be, will actually allow us to flex our production in order to build as much as we can here. We’re looking to do that regardless of the tariff situation. We can’t make moves simply because of the tariff situation. So while tariffs are problematic, they’re essentially a tax on the consumer. Obviously we are not in favour of them. The real litmus test for us in terms of local investment is can we be competitive in building what we sell here? That’s the lens through which we would view whether we would open up a new plant or not, or what kinds of additional investments we might make in our existing plant infrastructure.Q: President Trump has threatened to pull out of NAFTA if Congress doesn’t approve its replacement. What would that do to Toyota?A: When you assemble a vehicle in one state, but the parts can literally crisscross the border five or six times before it actually gets assembled to the vehicle, it’s very challenging to think of an outcome where the border actually becomes a barrier to our whole assembly process, our whole supply chain. That’s not just true of Toyota, it’s true of every automaker. So there’s common industry interest in making sure that there are as few barriers as possible. That’s why I’m optimistic that the Trump administration’s moves on USMCA will bear some fruit. We’re OK with where the USMCA landed.Q: What percentage of vehicles that Toyota sells in the U.S. are built in North America and in the U.S.?A: Roughly 74 per cent. Fifty per cent is U.S. only, and that’s growing. We were on that track before this sort of spasm on trade and tariffs.Q: If the U.S. imposes 25 per cent tariffs on imported vehicles and parts, Toyota has said there would be significant price increases for vehicles built in the U.S. The price of the Camry midsize car, which has among the highest U.S. parts content, would rise by $1,800. Why would the Camry price go up?A: There’s no 100 per cent U.S.-made product. Every vehicle from every manufacturer has some amount of componentry that comes from somewhere else. We’ve got to be able to absorb those costs. And where we can’t absorb them, what tariffs do to you is they compel us and every other manufacturer to pass those costs on. Let’s not forget the steel and aluminum tariffs. They also have an impact, and not a positive one. So that’s why you’re seeing the risk on price even for a vehicle like a Camry.Q: Auto sales in the U.S. are expected to slow, especially of cars. Yet Toyota and Mazda are jointly building a new factory in Alabama that would build cars. Why do you need more factory capacity in a declining market?A: Our view of the market goes beyond the normal cycle. We’ve got to be able to plan beyond that and anticipate where the market will be not just next year but over the next decade or so. We think there’s a future in passenger cars. We think there will always be a need for that. We’re actually excited about the fact that some of our competitors might be exiting that segment. We view it as an opportunity in the medium term to long term.Tom Krisher, The Associated Presslast_img read more

6 10 19

Secretary-General Kofi Annan’s Special Adviser Lakhdar Brahimi and the Under-Secretary-General for Peacekeeping Operations Jean-Marie Guéhenno tomorrow will begin weeklong visits to Africa’s largest country.Mr. Brahimi, who has been in close contact with the AU on the scope and nature of UN support to the Union’s mission in Darfur, will be following up on those contacts during his visit, which will focus on the war-riven region in Sudan’s west.The purpose of Mr. Guéhenno’s fact-finding mission is to gain the best possible understanding of the situation in wider Sudan, as well as the UN response.

3 10 19

Sino-Forest defrauded investors and misled investigators, OSC rules by The Canadian Press Posted Jul 14, 2017 7:18 am MDT Last Updated Jul 14, 2017 at 12:20 pm MDT AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to RedditRedditShare to 電子郵件Email TORONTO – Timber company Sino-Forest and several of its top executives defrauded investors, misled investigators and “engaged in deceitful or dishonest conduct,” the Ontario Securities Commission ruled in one of Canada’s largest corporate fraud cases.In a nearly 300-page decision released Friday, the regulator said the company and former CEO Allen Chan, as well as Albert Ip, Alfred Hung and George Ho defrauded investors by overstating the now defunct company’s timber assets and revenue.Allegations of fraud against Simon Yeung were dismissed, but the regulator concluded he misled staff during their investigation.The investigation into Sino-Forest was triggered in 2011 when short seller Carson Block of Muddy Waters Research published a scathing report accusing the company of exaggerating its assets and fabricating sales transactions in what amounted to “a multibillion-dollar Ponzi scheme.”“We applaud the OSC for persisting through an undoubtedly complex investigation and hearing to see that justice is served,” Block wrote in an email Friday.“It’s important to remember that our report was initially quite controversial and met with a good deal of hostility — at a time when the freedom of speech is under threat, this outcome is a reminder of the value of critical voices and freedom of expression.”The former executives now face the possibility of being permanently banned from Canada’s capital markets, or fined up to $1 million for each failure to comply with Ontario securities law.A separate hearing on sanctions and costs has not been set.Chan’s lawyer, Emily Cole, said her client was disappointed and would be going over the decision. Stephen Wortley, a lawyer for Ip, Hung, Ho and Yeung, said he was also reviewing the decision and declined further comment.Sino-Forest, which was established in 1994, was once the most valuable forestry company listed on the Toronto Stock Exchange. Although it was based in Ontario, the company conducted most of its business in China until it collapsed in 2012.The decision by the OSC follows the settlement of several lawsuits by investors in connection with the case.In 2015, several Canadian banks and other financial institutions that helped the company raise millions on the financial markets agreed to a $32.5-million settlement in a class-action lawsuit filed by investors who lost money.David Horsley, former chief financial officer of Sino-Forest, also agreed to pay $6.3 million to the OSC and to settle class-action lawsuits in 2014, while Sino-Forest’s former auditor, Ernst & Young, agreed to a $117-million class-action settlement with investors in 2013.The case against Sino-Forest and its former executives was one of the most complicated cases in the Ontario Securities Commission’s history.“Today’s decision on the merits is an important milestone in a complex, multi-jurisdictional case that spanned close to 200 hearing days and involved over 2,000 exhibits,” the commission said in a statement.The hearing heard testimony from several witnesses from China over video conferencing and with the assistance of translators. There were more than 170 hearing days, 22 witnesses and over 22,000 pages of transcripts.Defence lawyers for the executives had argued that what the OSC called fraud were simply mistakes made by a fast-growing company. They also said that behaviours that may seem strange in a Canadian context were typical business customs in China.But the commission said Sino-Forest was listed on the TSX, was an Ontario reporting issuer, raised US$3 billion from investors, and was required to issue financial statements prepared in accordance with Canadian standards.“Ontario securities law is paramount and overrides any explanations for illegal conduct being excusable in the name of guanxi, however it is defined,” the commission said in its decision, using a Chinese term that refers to a network of influential relationships that help facilitate business dealings.— By Craig Wong in Ottawa read more

25 09 19

first_imgMs Newman inherits the estate under the terms of the 7th Baron’s will, made before he died in 1941. It stated that if any Lord Braybrooke failed to produce a male heir, the estate should revert to his line. She is his granddaughter. “It seems rather hard on Amanda. She’s lived and worked there all her adult life,” Julian Fellowes told the Sunday Times. Mrs Murray has previously said the law is “discriminatory” and that she was already “doing a man’s job” in running the estate. “It boils down to this,” she said. “If I was a boy, I would be sitting pretty. In Downton Abbey, cousin Matthew Crawley becomes the heir to the estate of the Earl of GranthamCredit:NICK BRIGGS/ITV The creator of Downton Abbey has criticised inheritance laws after a baron’s daughter lost her father’s title and land. Lord Fellowes of West Stafford said that Amanda Murray, 55, daughter of Baron Braybrooke, had been unfairly penalised by laws in the peerage which prioritise male heirs.  Robin Neville, the 10th Baron Braybrooke, died last week, leaving seven daughters – but none of them will inherit his title or the 6,000-acre Audley End estate in Essex.Instead, the title goes to a distant cousin, Richard Neville, 40, director of Bring a Bottle, a price comparison site for alcohol, and the estate to Louise Newman, 56, an art historian. Lord Braybrooke outside Audley End House “My poor father had no son; just lots of daughters. In this day and age, with supposed equality, why am I not allowed to inherit my father’s estate?” In Downton, cousin Matthew Crawley becomes the heir to the estate of the Earl of Grantham The situation was dubbed the “real-life Downton” because of its similarities to a storyline in the TV show Downton Abbey, in which a distant male cousin becomes the heir to an Earl who has three daughters but no sons. The Royal laws of succession were changed in 2013 ahead of the birth of Prince George, and are now gender-neutral. But Fellowes said changing the peerage rules to match was not an easy fix.“Simply making the peerage…the equivalent of the royal family would create a great chaos for many families…whose sons have for 30, 40, 50 years made the assumption of inheriting. One can’t just brush them aside,” he said. Fellowes has previously said it was “outrageous” that his wife, Emma, a descendant of Earl Kitchener, the famous First World War field marshal, had no right to inherit the title when the third Earl, who was childless, died in 2011. Lord Braybrooke outside Audley End House Want the best of The Telegraph direct to your email and WhatsApp? Sign up to our free twice-daily  Front Page newsletter and new  audio briefings.last_img read more

22 09 19

first_imgThe Montrose Hotel — soon to be reopened as the ‘Montrose Student Residence’ THE MONTROSE HOTEL, a well-known Dublin 4 landmark just across the road from UCD and a short walk from RTÉ’s Donnybrook campus, is to be redeveloped for student accommodation.Third level and graduate students “Dublin-wide” will be targetted for the development through the academic year, and it’s planned the property will be used for international language students during summer months.The revamped ‘Montrose Student Residence’ will open for business in September.The plan — being helmed by Ziggurat Student Living — will see the hotel redeveloped to offer 192 bedroom units, arranged “in a choice of five to eight bedroom ‘cluster flats’ each with communal living, kitchen and dining areas”.It’s planned the residence will also offer round-the-clock security, on site laundry and car parking spaces. Utilities, broadband internet and contents insurance are all included in the room rental, according to the developers, and it’s projected rent will start from €175 per week, based on a 42 week term.The €22.5 million project is the first Irish development by the firm, which says it plans to create over 1,000 student bed spaces in the city over the next five years.According to the company:Privately owned and managed bespoke student accommodation, as an alternative to on-campus housing, is an increasingly attractive option for students and their families.Ziggurat is currently working on similar projects in Edinburgh and Newcastle, and says it’s also making efforts to launch a second scheme in Dublin.Image: Google MapsRead: Dublin seen as hot property in Europe’s real estate marketRead: Relics of the boom: What now for the banking sector’s landmark real estate sites?last_img read more

20 09 19

first_imgSida : nouvel espoir de traitement grâce à des chercheurs israéliensIsraël – Quatre chercheurs de l’université hébraïque de Jérusalem ont décrit le 19 août dernier  la façon dont ils ont provoqué, en laboratoire, l’autodestruction de cellules infectées par le virus de l’immunodéficience humaine (VIH). Des résultats prometteurs, décrits dans la revue médicale AIDS Research and Therapy.Alternative aux méthodes développées jusqu’à présent, visant à détruire le VIH à l’intérieur des cellules infectées, la technique proposée par l’équipe d’Abraham Loyter consiste à induire l’autodestruction des cellules hôtes du virus sans affecter les cellules saines.À lire aussiSIDA : 10 symptômes qui doivent alerterUtilisant des peptides (polymères d’acides aminés), le procédé éviterait notamment les risques de regain de l’infection en cas d’arrêt du traitement et le développement d’une immunité  par le virus, deux problèmes rencontrés avec les autres thérapies.  Les auteurs estiment  que leurs travaux “peuvent éventuellement aboutir à une nouvelle thérapie générale”. Un nouvel espoir pour les malades, alors même qu’en juillet, des chercheurs américains annonçaient la découverte en laboratoire de deux anticorps efficaces contre la plupart des souches de VIH, prometteurs en termes de vaccination contre le sida.Le 6 septembre 2010 à 16:16 • Emmanuel Perrinlast_img read more

19 09 19

first_imgFind out what it might be like outside this week with our local weather coverage.Here are some of the stories that grabbed our readers’ attention this weekend.ACLU sues Vancouver-based PeaceHealthA longtime worker for a Catholic health care system in the Northwest sued the organization Thursday, saying its employee insurance plan refused to cover gender-reassignment surgery for her teenage son.The American Civil Liberties Union of Washington filed the discrimination lawsuit against PeaceHealth in federal court on behalf of Cheryl Enstad of Bellingham and her son, Paxton Enstad, 17. She said she and her husband eventually took out a second mortgage and dipped into Paxton’s college fund to pay more than $10,000 for his surgery last fall.“PeaceHealth was telling me my son was undeserving of medical care simply because he’s transgender,” Cheryl Enstad told a news conference Thursday. “It’s heartbreaking. It is not fair.”Woman in critical condition after fall from horse in RidgefieldParamedics rushed a woman to the hospital in critical condition after her neighbors found her on the ground unconscious after an apparent fall from her horse Thursday.Clark County Fire & Rescue spokesman Tim Dawdy said firefighters were called to in the 25000 block of Northeast 18th Court in Ridgefield around 2:15 p.m.last_img read more

10 09 19

first_img 10 Photos VW will build Sedric, this self-driving concept pod Volkswagen Autonomous Vehicles Car Industry Auto Tech Post a comment Share your voice News • 2019 Volkswagen Arteon is pricey, starting from $36,840 Self-driving cars Join us for a ride in Ford’s prototype self-driving car Now playing: Watch this: 2020 BMW M340i review: A dash of M makes everything better 2019 Lamborghini Urus review: Part SUV, part supercar 0 2020 Hyundai Palisade review: Posh enough to make Genesis jealous Preview • 2019 Volkswagen Arteon first drive: Flagship fastback feels familiar Tags More about 2019 Volkswagen Arteon 5:57 Review • 2019 Volkswagen Arteon review: VW’s CC followup is more than just a carbon copy More From Roadshow Enlarge ImageI’d probably feel carsick, too, if I was getting driven around with that thing on my head. Volkswagen It took me years to condition myself to be able to look at my phone from the passenger seat of a moving vehicle without getting nauseous, and there are countless others still trying to make that happen for themselves. When self-driving cars begin to litter the landscape, occupants might be rightfully worried about how the cars will drive and whether or not they might make people sick. Thankfully, Volkswagen is trying to figure out ways around that.Volkswagen last week published a release chronicling the ways that the automaker is attempting to mitigate car sickness for passengers of autonomous vehicles. The OEM is looking at two specific things: What makes a person sick in a car, and how to mitigate that in the future.To figure this out, Volkswagen is putting people in cars and making them sick (really). In its release, it mentions a specific scenario: A volunteer wears sensors and cameras to measure various things like pulse and body temperature. That person is taken around a test track, following behind a semiautonomous vehicle operating “in a stop-start motion,” mimicking traffic. The volunteer must watch a video displayed on a dashboard-mounted tablet the whole time the test is running. The test passenger mentioned in the release said she doesn’t normally get carsick, but in this test, she did.VW is trying to figure out ways to mitigate this onset of nausea. The automaker mentioned the idea of movable seats that could physically react to changes in vehicle physics, as well as a set of LED light strips that tell users when the car is braking or accelerating, hopefully syncing up the brain and inner ear with the motions experienced through the vehicle. VW claims that there has been “some initial success,” but it’s still working to ensure that whatever countermeasures it devises will be useful for those in the real world.It doesn’t take a self-driving car to make you nauseous as a passenger, obviously. I felt under the weather trying to operate a trunk-mounted camera while riding shotgun around a track, and it took fewer than three laps to start feeling unwell. Taking my eyes off the screen and focusing solely on the horizon did help, but when it comes to autonomous cars, one of their perceived benefits is the ability to get some work done on a commute, and immediately getting carsick would negate that. VW’s smart to try and get ahead of this, lest we find a whole subset of civilization unsuited for AVs from a gastrointestinal standpoint.last_img read more

5 09 19

first_imgHindustan Unilever reported disappointing earnings for the quarter ended 31 December, 2015. Net profit fell sharply by 22.4% year-on-year to Rs 971 crore, while revenues grew at a modest 2.7% to Rs 7,981 crore from Rs 7,774 crore in the corresponding period in fiscal 2015.The overall volume growth was 6%.”The growth in the quarter continued to be impacted by the phasing out of excise cuty incentives and price de-growth, as the benefit of lower commodity costs was passed on to consumers,” the company said in a statement.”Net Profit at Rs.971 crores was impacted by the exceptional income from the sale of properties in the base quarter and provisions for restructuring & select contested matters,” it added.”In an environment of moderating growth and benign input costs, we remain focused on innovation and market development to drive volumes competitively whilst improving operating margins,” said Harish Manwani, Chairman, Hindustan Unilever, in his statement.Its soaps and detergents business grew by just 1%, which was attributed to price deflation due to falling input costs, which was passed on to consumers.Personal products grew by 5% while growth in the beverages segment remained unchanged at 7%.Falling crude oil prices benefitted the company during the quarter under review, with cost of material dropping to Rs 2,689.39 crore, down 7.4% from Rs 2,860.63 crore in the corresponding quarter ended 31 December, 2014.On Friday, shares of Hindustan Unilever hit a new 52-week low of Rs 776.60 on the BSE before closing at Rs 804.15, down 2.7% from its previous close.The company’s advertisement expenses fell marginally to Rs 1,137.79 crore during the third quarter ended December 2015, though the company’s brands continue to figure in the list of leading brands advertised on television. For the week ended 8 January, 2016, three of the company’s brands were on the list of top 10 brands, according to Broadcast Audience Research Council, India.The company’s rival, Proctor & Gamble Hygiene & Healthcare, will be declaring its results on 6 February, 2016.last_img read more

5 09 19

first_imgEmployees of Infosys Technologies Limited walk in the campus of the company’s headquarters in Bangalore on April 13, 2017.MANJUNATH KIRAN/AFP/Getty ImagesUpdate at 3.17 PM: Wipro recovered from its lows to trade at Rs 525.75, down 2.05 percent while Infosys was trading 1.47 percent higher at Rs 962.60, while Biocon gained 1.26 percent to trade at Rs 1,033 after the GST Council reduced the tax rate on insulin from 12 percent to 5 percent.The BSE Sensex was down 166 points to 31,095, dragged by Tata Motors, L&T, Wipro and ICICI Bank. Wipro shares go ex-bonus from Tuesday (June 13) while the record date for the 1:1 bonus shares is June 14, 2017.Update at 10.50 AM: Wipro shares crashed almost 3 percent to hit an intraday low of Rs 521.40 in response to the company flagging off Donald Trump’s victory in the US presidential elections as a factor affecting growth. Infosy was also down 0.81 percent to Rs 941.”On November 8, 2016, Donald J Trump was elected the next President of the United States. As a candidate, Trump expressed support for policies impacting existing trade agreements, like North America Free Trade Agreement. He also proposed trade agreements, thus, promoting greater restrictions on free trade generally and significant increases tariffs on goods imported into the United States,” Wipro said in a regulatory filing with the US Securities and Exchange Commission (SEC).”Social, political, regulatory and economic conditions or in laws and policies governing foreign trade, manufacturing, development and investment in the territories and countries where we currently operate could adversely affect our business,” the company added. Original story:Political uncertainty in Europe, especially in the UK after election results threw a hung parliament, led to weak opening on Asian stocks markets on Monday, impacting India. The BSE Sensex opened about 150 points lower to hit 31,106 but partially recovered later to trade at 31,140, down 122 points, at around 9.45 am. Top losers were Wipro (down 2.6 percent to Rs 522), TCS and Adani Ports while stocks bucking the trend included Sun Pharma, Maruti Suzuki India and GAIL (India).The bearish opening for Indian stock market was on predicted lines. “Indian markets are likely to open flat and may trade in positive zone tracking the SGX Nifty and Asian markets,” brokerage Angel Broking said in a note on Monday morning.The government will be releasing May retail inflation data and April factory output (IIP) after markets close for the day on Monday. Finance minister Arun Jaitley will be meeting chiefs of public sector banks to discuss a slew of developments and initiatives, including NPAs.Brokerage Nirmal Bang Institutional Equities has forecast retail (CPI) inflation to come at 2.3 percent, lower than the record low of 2.99 percent posted for April.”May 2017 Consumer Price Index or CPI inflation is likely to come in at 2.3 percent, lower than the 3 percent reading for the previous month,” Teresa John, economist at brokerage Nirmal Bang Institutional Equities, said in a note on Friday.”The decline in CPI inflation can be attributed to the fall in food inflation, particularly continuous disinflation in pulses, and soft vegetable prices combined with the base effect,” she added.GST updateAfter tweaking tax rates on 66 items such as cinema tickets, cashew, insulin, incense sticks and computer printers, at its meeting on Sunday, the Goods and Services Tax (GST) Council will be meeting on June 18 to review its preparedness for rolling out the GST rates from July 1 2017.Petrol, diesel prices for Monday, June 12(The daily price mechanism currently valid in five cities will be extended to the entire country from June 16).  www.ioc.com A car enters an Indian Oil fuel station in New Delhi, August 29, 2016.Reuters filelast_img read more

3 09 19

first_imgFour people were killed in separate road accidents in Dhamrai, Savar, Narail’s Kalia upazila and Munshiganj on Saturday.Police identified the deceased as Md Ali Arshaf, a retired army officer from Barishal, Md Mosharraf Hossain, son of Munayem Gazi of Patuakhali, Ekramul Sheikh, son of Rizzak Sheikh of Narail and Md Mostofa of Bhola.Ashulia police sub-inspector Jaminur Rahman said Arshaf was killed after being run over by a speeding bus on Dhaka-Aricha Highway in Nabinagar in the morning.In a separate accident, Mosharraf was killed and four others were injured after the microbus they were travelling in overturned at Dhamrai, said sub-inspector Promoj of Dhamrai police station.Meanwhile, Anwar Hossain, in-charge of Kalia police station, said peddled-van driver Ekramul was killed and two others were injured after a brick-laden vehicle ran them over at Chowrasta area around 11:00am.The injured – Minhaj Gazi and Razina Khanam – were admitted to Khulna Medical College Hospital in critical condition, the OC added.Mostofa was killed when a brick crushing machine fell into ditch at Pauldia area, said dub-inspector Niranjan Ray of Sirajdikhan police station.last_img read more