An early morning accident on the Linden-Soesdyke Highway has claimed the life of 30-year-old Simon Paul of Victoria village, East Coast Demerara, an employee of the Georgetown Public Hospital Corporation (GPHC).Paul was reportedly proceeding in a northerly direction along the highway, heading towards Georgetown in his car, PVV 9105, when he collided head-on with a truck heading to Linden, Region 10.This publication was told that the accident occurred in the vicinity of Hararuni at about 00:30h, and preliminary investigations indicate that Paul was probablySimon Paul’s ill-fated vehicle (Photo courtesy of Gordon Moseley)speeding when he apparently lost control of the car and slammed head-on into the truck.He was reportedly flung from the car, and his body was discovered on the highway, some distance away from the scene of the accident. The car’s roof was completely ripped off, while extensive damage was seen to its front and rear. Both windscreens were smashed inwards.The driver and the porter of the truck were taken to the Diamond Diagnostic Centre, where they were treated and sent away. However, the driver of the truck has been taken into custody as investigations into the fatal accident continue.
A pervert who sexually abused two young girls at a caravan park in Portsalon has been jailed for four years.Letterkenny Court.The man committed the crimes on the two young girls, who were aged just 11 and 12 at the time. The man was sentenced at Letterkenny Circuit Court today where he pleaded guilty to all four charges of sexual assault.Judge Keenan Johnston said the assaults were a fundamental and fatal breach of trust by the man.But he said the sentence must be proportionate to the crimes committed.Of the young girls trauma, Judge Johnson said the victims should not blame themselves as they had ben.“They have been robbed in the most serious way of their childhood,” he said.He also ordered the man to be observed for five years after he is released and to be placed on the Sex Offenders Register for life.The four incidents, which he pleaded guilty to, happened between January and May 2010 while the girls were visiting their relatives’ mobile home.Letterkenny Circuit Court was given graphic details of the incidents.The court heard the victim impact statements form both young girls who were aged around 11 or 12 when the attacks happened.One of the girls had tried to kill herself and the other blamed herself for the assaults.The court heard how three of the assaults took place in the caravan park and another while on a walk.The accused, who is originally from Derry, was arrested by Gardai after one of the girls complained to her teacher about an assault.After he was arrested and released, the man and his wife moved to Spain.Garda Sgt Bridget McGowan said Interpol then acted on a European Arrest Warrant for the accused and he was deported to Ireland in July 2013.He has been in custody since.The court heard the man has one previous conviction for indecent exposure.Relatives of the two girls who were abused sobbed at the back of the court as the man was sentenced.PERVERT WHO ABUSED TWO GIRLS AT CARAVAN PARK JAILED FOR FOUR YEARS was last modified: February 5th, 2014 by StephenShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window) Tags:abuseDerryGirlsPortsalon
SAN JOSE — Martin Jones’ preseason numbers were not pretty. Neither was his season-opening start against the Anaheim Ducks.But searching for any concern about Jones and his so-so play so far inside the Sharks’ dressing room right now is pointless.History shows he’ll bounce back.“One of the great things about him is he always responds well to that type of situation,” Sharks coach Pete DeBoer said. “He has an off night, it’s almost money in the bank that the next time out, he’s really …
Share Facebook Twitter Google + LinkedIn Pinterest The Ohio Department of Agriculture announced that eight land trusts, four counties and 15 Soil and Water Conservation Districts will receive funding to help preserve farmland across the state. These organizations will receive allocations from the Clean Ohio Fund to select, close and monitor easements under the Local Agricultural Easement Purchase Program (LAEPP).LAEPP sponsor organizations will accept applications from Ohio landowners interested in selling an agricultural easement on their farms. A total of nearly $8.5 million will be made available in this funding round. Local sponsors have been certified to accept applications in 34 counties. Interested landowners should contact the certified local sponsor in their county for application details.The program allows landowners to voluntarily sell easements on their farms to the state of Ohio. The easement requires the farm remain permanently in agriculture production. Selected farms must be 40 acres or more, actively engaged in farming, participate in the Current Agricultural Use Valuation program, demonstrate good stewardship of the land, have the support of their local government and not lay directly in the path of development. Landowners may use the proceeds of the easement in any way they wish, but most reinvest it in their farm operations.Funding for the program is derived from the Clean Ohio Conservation Fund, approved by voters in 2008. When combined with easements from all programs, 449 family farms in 59 counties have collectively preserved more than 73,500 acres in agricultural production. For more information on Ohio’s farmland preservation effort visit: www.agri.ohio.gov/wps/portal/gov/oda/programs/farmland-preservation-office.
By Jennifer Rea“Babe, I’m thinking about applying to Officer Candidate School (OCS)…”My heart sank in my chest and my head ran to every negative connotation of my husband being in the military AGAIN—deployments at least 7 months long, everything falling apart, my anxiety and fear of being alone at night and the painful move as I left my family and friends for the first time.“Well, I don’t do life as just OK. I’m not the kind of person that does the 9 to 5 job and is happy with it… I need something more.”To provide you with a little background… my husband (JR) and I met in 6th grade for the very first time when he moved from private school to public school. In 6th grade, JR and I dated for a week, but broke up because one of my close friends wanted to date him… strange how things work out! We actually reconnected, at a more mature level, in our 10th grade Algebra class.It’s funny to me to look back on the first day of that Algebra class and remember that JR’s pick up line (via MSN Messenger) was “Hey, you looked beautiful today in math class! We should hang out sometime.” His courage and confidence anchored me in and I was hooked.My high school sweetheart became my husband on June 16, 2012—after 5 years and 8 months of dating (finally!). At that time, my husband had already been in the Marine Corps for two years and was stationed in Jacksonville, North Carolina. Much of our relationship at the time was long distance with emails, snail mail, Skype, Facebook, and MSN Messenger to help us stay connected while 1,300 miles apart—I thank God for technology!Two short days after we got married, JR and I spent our “honeymoon” packing up a U-Haul and my two-door Civic, driving cross country (from Minnesota to North Carolina) in separate vehicles…a perfect way to spend your honeymoon, right?We were both very excited as we had never lived together before and were finally together in the same house let alone in the same community for the first time in two years! With the happiness, there also came struggles and challenges for both of us. Learning to live together was one thing, but having to adapt to the military lifestyle and culture was another.I had never grown up with anyone that was close to me that was in the military besides my grandfathers, however they had been retired for several years so, I had never known what “military life” was like. I now believe that knowing what the military lifestyle can only be understood by the military family themselves. I say this not to offend anyone, but to point out that I personally have seen several differences between “military” and “civilian” life. The first, as a military family I conceptualize the absence of my husband being gone quite differently than I would have not being a military spouse. Although it is difficult when he is gone—I am very proud of my Marine for serving our country and having such dedication to his work.A second piece is that the military is a “culture”—it has its own language, way to act, and attire. I recognized this difference when I went on the military base for the first time. It was obvious who was not a service member based on the haircut and the attire and I definitely felt as if I stood out like a sore thumb!Another piece was trying to learn the language and all the acronyms! Many of the get-togethers we had at our house involved the gathering of service members that my husband worked with (his friends) and their spouses. When it was just me and the “guys” I had no idea what they were talking about and felt left out of the conversation several times due to their acronyms and work lingo—I was very thankful for the military spouses I had met, which brings me to my next item—a military family.As I had previously mentioned, the military is a culture and part of this culture involves several military families—this is the piece I loved the most! While not all military spouses get along, there are many military spouses that I could confide in and know that they would have my back no matter what. The part where you’re able to connect with someone going through the same situation as you and being in the “military spouse club” are things I really valued and enjoyed.I had never been that far away from my parents, my family and my friends so the whole transition was very difficult for me. I think JR struggled too, with looking for a way to help me, when really there wasn’t much he could do. I just needed to adjust so time and patience were key factors for me.The biggest thing that helped me adapt in the transition was being open and willing to meet new people, which I know was difficult at the time, even for me, as a social butterfly. Secondly, I got a job and I kept busy. I was actually enrolled in North Carolina State at the time to receive my M.S. in Family Life and Youth Development. I ran across a really great job—so, all of these things really helped me adjust. I also tried to continue the hobbies that I was used to doing in Minnesota, such as running, going to the gym, workout classes and crafting. I really enjoyed exploring the town and the Carolinas—of course, I can’t forget about the beach.So, fast-forward to the transition we are in now… honestly, I kind of saw it coming. JR had a really hard time “leaving the military” and transitioning to “civilian life”. The beginning of our drive home to Minnesota was very emotional for him—it was like he was leaving his family. I felt really bad for him and felt guilty that I “made” him decide to move back home. We struggled during this transition too, as change is hard for both of us. JR wasn’t happy with his civilian job and I honestly hate when he’s unhappy—I feel helpless.Watching JR in the “civilian world” was challenging. He hasn’t had anyone to really connect with unless he called his other service member buddies on the phone and man, those phone calls made his day! Again, it was almost as if he lost his family. The military had been part of his life for 5 years and he was used to the strict schedule, a consistent and reliable career with benefits, and was challenged with every day routines. I believe that the most difficult piece for JR was looking for a job—sending out resumes and going to interviews—this is something JR hadn’t done in 5 years! The second was financial. I know there were many times we talked about how we were going to pay our bills, and wondered if his job would be able to support us. It was stressful, but we were both on the same page on budgeting and managing our finances, so I think that helped a lot! And then JR found a job that was more stable than working construction, which helped with the financial piece and the benefits. For more “excitement” and to challenge his skills, JR applied to college and this really seemed to bring up his spirits. Many times he would come home from school and tell me all about class; what they talked about, how it relates to being in the military, and everything he had been learning. It was exciting and encouraging to know that he was “satisfied” with at least one piece in his life.So, the conversation came up several times, and I think we both really needed to soak it in. I was angry, sad and anxious at the thought of him being in the military again. I felt like it was his decision and he hadn’t even thought about “us.” Throughout the process, he kept saying, “I’m sorry… I don’t want to do this to you again.” And I just thought, “Well, don’t then.” I asked myself, “Can I do this again? What are the benefits and do they outweigh the downfalls?” I appreciated his sympathy and concern in the matter, but I struggled in understanding why he wanted to join again…I ended up reassuring myself that this was inevitably JR’s decision, however he had made the decision for us—for our future and our future family. I didn’t realize this until actually two weeks before he left for OCS. We had just been driving home after getting ice cream as I was stressed with finals and thinking about JR leaving. We had just pulled into the garage and I had asked him, “So, really, why do you want to join OCS?” And he looked at me and replied, “I want to do this for our family. I struggled growing up—not having the finances to be able to go to college, barely being able to pay the bills and all the other financial aspects— it really stresses me out and I don’t want that for our family. I want us to be able to travel, to take off and fly wherever we want, whenever we want. I also want our kids to be able to go to college and I want to financially support them. I love the thrill of being in the military, it’s fast pace and motivating, but also I enjoy the fact that it is simple for me—there are set hours, pay and benefits, but also opportunities for challenges and goals to achieve. I hate that I have to leave you again and miss you every time I’m gone—this is the worst part for me, and the reason why we got out in the first place. But the way I see it now, there are many more opportunities for us in the military then just saying here.” Amazed—is the word that I describe how I felt in this moment—JR always seems to amaze me and surprise me with what he believes, his opinions, and his drive—all the reasons why I wouldn’t want to be without him. So, we decided if he goes, I go.No one really understands why individuals want to join the military or better yet why someone would want to “follow” and go with them! But from my experience, I recognized that the individuals that do are amazingly selfless and humble people who want to make a difference in not only their lives, but a majority of their focus is to make a significant impact in the lives of others. This in itself motivated and encouraged me to “allow” or accept JR’s desire to re-enlist and apply to Officer Candidates School. I was also reassured by God’s love and knowing that he has BIG plans for JR and I—much greater than we would’ve ever thought! Oddly enough, I feel so incredibly blessed and thank God every day for JR. He is the most intelligent, caring, loving, selfless, and supportive man I have ever met! Together, we make a great team and a military family.Looking toward the future… I definitely see my future differently than I did when we had moved home to Minnesota last August. The biggest difference is knowing that I won’t be living in Minnesota for the rest of my life—this piece hurts, A LOT because it’s home—its where my family is, my friends, my memories, everything. The second item is my career. I am currently going to the University of Minnesota to receive my PhD in Family Social Science and I hope to teach in a university someday, however knowing that my husband is now becoming a Marine officer—it’s a slightly different story. For one, JR will be active duty again so, this means that there will be at least one year where we will have to manage long distance again, which sucks, but I want to finish my schooling here in Minnesota before moving from place-to-place. Secondly, there are not many universities near military bases, especially Marine Corps bases. So, currently, I’m envisioning that I will either teach at a community college, which could be fun or find a career working for the DoD or a military base – teaching, researching, or program design and evaluation. So, we’ll see! And the third is our future family. When we came home, I was thinking about having our first child when I was like 25, but now with my graduate program and JR going active duty again, we both have decided that children will have to wait a little bit longer—at least until JR gets somewhat permanently stationed and I finished my degree—sorry, Mom and Dad! So, the first major milestones, while we did purchase our first house in December, it looks like we’ll only be able to keep it for 3 years and then move to somewhere else, where I’m assuming we will probably have to rent/live on base. And then children probably a little later in life, around 27 years old—all of which can have its benefits and limitations.So, today… I haven’t seen JR in a month, not the longest we’ve been apart, but the most time we haven’t been able to talk since his first boot camp. For the first 3 weeks of OCS training, the only communication that we had with each other was snail mail! It’s been difficult not being able to come home and eat dinner with JR, go on walks, enjoy the summer weather, or simply share how our days went. Fortunately, after the third week, JR was able to call me and we Skyped for a while too so, that was really nice. It is hard for me to see him and talk to him, and then he has to leave and our communication gets completely cut off for a week—major bummer! During this time however I’ve been working at school, doing research, and working on a paper that is due later on in my program. As I had mentioned earlier, it is easier for me to deal with the transition and time apart if I stay busy and continue to send my brain messages that “it will be okay. He will be home soon!” I also make lots of plans to hang out with people because sometimes I really don’t feel like doing anything and if I stay home, I just get more sad and lonely. So, forcing myself to go out and spend time with good family and friends has been really helpful for me to get through this summer being away from JR.
Maruti Suzuki is all set to launch their much awaited product, the new generation Dzire in India on May 16. Yes, you read it right. Along with the cosmetic changes to the 2017 Dzire, Maruti Suzuki have also tweaked the name of their compact sedan. The new generation Dzire drops the Swift tag from its name, because the people at Maruti thought that its time that the compact sedan has its own brand name. So, in comes the new generation Dzire.Since its launch in 2008, Maruti Suzuki have sold approximately 13.8 lakh units of the Dzire. According to the people at Maruti, one out of every 2 compact sedan sold in India, is the Dzire. So let’s take a look at what’s changes have come in with the 2017 Dzire from its predecessor.Design:2017 Dzire: The new generation Dzire will come with a completely new and fresh look. Maruti Suzuki Dzire has been redesigned with a hexagonal grille with a chrome strip around it. The front bumper and the headlamp cluster gets an appealing makeover. At the rear, the new generation Dzire gets minor cosmetic change as the tail lamps has a revised design. The new Dzire will also sport new projector headlamps, LED DRLs and redesigned alloy wheels.2017 Maruti Suzuki Dzire. (Photo: Rahul Ghosh)2015 Dzire: The 2015 compact sedan’s front bumper comes with a larger air dam. There are chrome accents on the sides around the fog lamp housings, while the grille now sports honeycomb styling and a thick chrome bar on the top. Moving on to the sides, the alloy wheels on the top variants get an all-new design. When it comes to rear space, the Dzire is not the best of the lot and the same is the case when it comes to its 315-litre boot which is the smallest of the lot here.advertisement2015 Maruti Suzuki Swift DzireEngine: 2017 Maruti Suzuki Dzire 2015 Maruti Suzuki Dzire Engine Type K Series Petrol Engine With VVT/ DDiS Diesel Engine K Series Petrol Engine With VVT/ DDiS Diesel Engine Displacement 1197cc/ 1248cc 1197cc/ 1248cc Power 83 bhp/ 74 bhp 83 bhp/ 74 bhp Torque 115 Nm/ 190 Nm 115 Nm/ 190 Nm Transmission 5-MT/ AGS 5-MT/ 4-AT Drive train FWD FWDFeatures:2017 Dzire: The new generation Maruti Suzuki Dzire will come with an upgraded list of features to compete with its competition in the segment. The list includes touchscreen infotainment system, Apple CarPlay/Android Auto Bluetooth, USB and Aux-in among others. Another added bonus to the new generation Dzire is that the car now comes with rear AC vents, which was not seen in the previous generation Swift Dzire.2017 Maruti Suzuki Dzire. (Photo: Rahul Ghosh)2015 Dzire: Inside not much was changed from a design point of view but the company has added features which add value. Things like electric folding mirrors, Bluetooth connectivity, rear parking sensors and a 12V socket at the back.2015 Maruti Suzuki Swift DzireDimensions: 2017 Maruti Suzuki Dzire 2015 Maruti Suzuki Dzire Wheelbase 2470mm 2430 mm Length 3995mm 3995 mm Width 1735mm 1695 mm Height 1515mm 1555 mm Ground Clearance 163 mm 170 mm Boot Space 376-litres 316-litresColors:2017 Dzire: The new Dzire will be available in 6 different colour options- Oxford Blue, Sherwood Brown, Gallant Red, Arctic White, Silky Silver and Magma Gray.2015 Dzire: The older Swift Dzire also came in 6 colour options- Silky Silver, Sangria Red, Alp Blue, Magma Gray, Cave Black and Pearl Arctic White.
Related Items: Facebook Twitter Google+LinkedInPinterestWhatsApp#TurksandCaicos, September 6, 2017 – Providenciales – It is certain now that parts of the Turks and Caicos Islands will get a direct hit from Hurricane Irma scheduled to impact overnight on Thursday. I encourage all the residents and visitors of these islands to seriously prepare. Do not take this hurricane likely – it is an unprecedentedly dangerous – a strong Category 5 hurricane with wind speeds up to 185mph and tide surge potentially up to 30 feet. Please listen for weather advisories and heed the advice given by authorities.Residents of Salt Cay, and Middle Caicos I encourage you to take the advice of authorities in your area for evacuations, and those living in coastal areas should either move inland or to high floors.Ensure that your home is properly secured and your surroundings are cleared of any possible debris. Those in flood prone areas are especially advised to take heed in securing your property. Please make use of the Hurricane Shelters if you need to and have all that you may need at the shelter including food, clothing, toiletries, blankets, important documents, etc. Be sure that you have enough food and drinking water for each member of your family to last at least a day or two after the storm, as electricity may not return immediately. Fully charge all of your electronic devices including your additional/backup batteries. Check to ensure your flash lights and lanterns are working and have spear batteries on hand. Remember to protect all of your important documents in water-proof containers.Keep battery powered radios with you and listen for advisories/updates, as they become available.We are a resilient people and will make it through and I pray for God’s protection over us during this storm.Press Release: Washington Misick (Leader of Opposition) Facebook Twitter Google+LinkedInPinterestWhatsApp
WILMINGTON, MA — The Wilmington Board of Health held a brief 30-minute meeting on Tuesday, September 3, 2019 at Town Hall.EEE & West Nile VirusWilmington Health Director Shelly Newhouse reported that there’s been no positive tests for EEE or West Nile Virus in Wilmington mosquitos this summer.“We do typically get a positive West Nile Virus positive. We have in years past. Testing is still ongoing. We could still wind up with one, but Wilmington is currently considered low risk. There’s been no positive tests in town and we hope it stays that way,” Newhouse told board members. “The town’s Animal Control Officer has visited all the horse owners in town. All horses are inoculated. Owners have been given fact sheets and are aware of the seriousness.”Newhouse noted that the Central Massachusetts Mosquito Control Project is continuing to conduct regular sprayings in Wilmington, but will stop once the night temperature drops to 55 degrees.Highland Estates Subdivision Plan ApprovedThe Board approved a modified subdivision plan for Highland Estates. Highland Estates is a conservation subdivision on Hopkins Street, near Sarafina Way, with 17 houses proposed next to 7 acres of open space along Lubbers Brook. The developer made changes to lot lines as a result of relocating a septic tank, which necessitated the Board of Health to reapprove the plan before the Planning Board is able to proceed.Update On New RestaurantsHealth Director Shelly Newhouse updated the board on new restaurants opening in town. Newhouse recently conducted a first wave of pre-opening inspections of Michael’s Place Bar & Grille on Lowell Street and Tremezzo Pizzeria on Shawsheen Street (formerly Uncle Mickey’s).“I think Michael’s Place Bar & Grille will be opening soon,” said Newhouse, noting she was just in last week to conduct an inspection of the equipment and new bar. “And Tremezzo Pizzeria is moving right in shortly.” Newhouse says she will need to conduct additional inspections at each restaurant prior to their openings.In response to a question from Board of Health Chair Elizabeth Sabounjian, Newhouse revealed she was as much in the dark as residents are regarding the status of Casa Blanca, which is slated to move into the old Chili’s location at the Wilmington Crossing. Casa Blanca was originally eyeing a September 2018 opening, but the Mexican chain was affected by the Merrimack Valley gas explosions, closing its Andover location for two months.“I haven’t heard anything from [Casa Blanca] in awhile. It seems like they’ve stopped doing any work in their building,” responded Newhouse.Newhouse also noted that the Wilmington Farmers Market’s fall season runs until Sunday, October 13, 2019 on the Swain Green. And organizers will likely again hold a monthly indoor Winter Market similar to last year.The Board of Health also reviewed several food inspection reports and approved their August Meeting minutes. The Board next meets on Tuesday, September 17, 2019 at 5:30pm in Town Hall’s Room 9.Like Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email firstname.lastname@example.org.Share this:TwitterFacebookLike this:Like Loading… RelatedWilmington Board Of Health Urges Residents To Use Caution As Mosquitos Test Positive For EEE In AndoverIn “Government”BREAKING NEWS: More Mosquitos Test Positive For West Nile Virus In Wilmington, This Time Off Of Adams St.In “Breaking News”ALERT: West Nile Virus Confirmed In Mosquitoes From WilmingtonIn “Government”
© 2017 Phys.org Explore further Inspired by natural signaling cascades, chemists have developed synthetic cascades that modify a self-assembled supramolecular structures post-assembly. Researchers from the University of Cambridge have developed a synthetic cascade that is triggered by norbornadiene (NBD) and relayed by a cyclopentadiene (CPD) intermediate resulting in the triggered change of two supramolecular structures. Their work appears in Nature Chemistry.After a one-pot self-assembly of two supramolecular structures, the Nitschke group developed a post-assembly modification (PAM) technique via a covalent signal cascade. PAM reactions are limited by the need to be sufficiently mild that they do not damage the supramolecular structure. They also need to be chemoselective and produce product in near-quantitative yields to eliminate the need for extensive purification and isolation. Diels-Alder reactions are good candidates for these types of reactions.Pilgram, et al. developed a system that underwent inverse-electron demand Diels-Alder (IEDDA) reaction with the initial triggering molecule, NBD, and a tetrazine-edged FeII8L12 cube, and subsequent Diels-Alder reaction with the relay molecule, CPD, and a tetrahedral complex. Their studies verified that the reactions required the triggering molecule and the relay molecule in order to work.Specifically, the synthetic scheme involved first making the terazine-edged cube in a one-pot synthesis. It then underwent the IEDDA reaction between the tetrazines and the NBD trigger molecule. After conducting model reaction tests, they used 2-octadecylnorbornadiene giving a pyridizine-edged cube and a 1-octadecylcyclopentadiene intermediate. This intermediate served as a relay molecule that bound to the maleimides on the tetrahedral complex via a Diels-Alder reaction.In one test, the final reaction involved forming a CPD intermediates with sufficiently long alkyl chains that the tetrahedral product transfers from an organic polar phase to a non-polar phase. Notably, without the initial triggering molecule, the final product is not formed and does not move into the non-polar phase, thus demonstrating a synthetic signal cascade in which a molecule changes lipophilicity as a result of an environmental trigger.Additionally, because the cell’s signal transduction pathways are often regulated by both triggering species as well as inhibitors, the Nitschke group investigated potential inhibitor molecules to their synthetic cascade. They found that cyclooctyne served as a good inhibitor by competitively reacting with the terazine molecules over the NBD trigger.Finally, another key finding of their synthetic cascade is that when the tetrahedral structure is complexed with an anionic guest (PF6-), the guest remains intact even after post-assembly modification of the structure. This allows the guest molecule to be transported from the polar to non-polar phase, which has implications for medicinal and other applications where molecule delivery is hindered by polarity or other environmental features.Dr. Nitschke told PhysOrg that future research includes designing cascades of reactions that are capable of being pushed backwards under out-of-equilibrium conditions. According to Nitschke, “Cascades of out-of-equilibrium reactions that are geared together such that one sequence of reactions either up-regulates or down-regulates another are fundamental building blocks of life. Understanding how they might work could help us understand prebiotic chemistry, as well as help us design complex synthetic assembly lines where substrates are passed along between capsules that chemically modify them.” More information: Ben S. Pilgrim et al. Signal transduction in a covalent post-assembly modification cascade, Nature Chemistry (2017). DOI: 10.1038/nchem.2839AbstractNatural reaction cascades control the movement of biomolecules between cellular compartments. Inspired by these systems, we report a synthetic reaction cascade employing post-assembly modification reactions to direct the partitioning of supramolecular complexes between phases. The system is composed of a self-assembled tetrazine-edged FeII8L12 cube and a maleimide-functionalized FeII4L6 tetrahedron. Norbornadiene (NBD) functions as the stimulus that triggers the cascade, beginning with the inverse-electron-demand Diels–Alder reaction of NBD with the tetrazine moieties of the cube. This reaction generates cyclopentadiene as a transient by-product, acting as a relay signal that subsequently undergoes a Diels–Alder reaction with the maleimide-functionalized tetrahedron. Cyclooctyne can selectively inhibit the cascade by outcompeting NBD as the initial trigger. Initiating the cascade with 2-octadecyl NBD leads to selective alkylation of the tetrahedron upon cascade completion. The increased lipophilicity of the C18-tagged tetrahedron drives this complex into a non-polar phase, allowing its isolation from the initially inseparable mixture of complexes. (Phys.org)—Within the cell chemical messages are passed through a signaling cascade. This cascade can be a series of chemical reactions or molecular changes that spurn the next reaction in a kind of assembly line process. This is how the cell responds to its environment and how communication happens over (biochemically ) long distances. Chemists build new chemical structures on unreactive bonds Citation: Covalent post-assembly modification cascade of self-assembled supramolecular structures (2017, September 6) retrieved 18 August 2019 from https://phys.org/news/2017-09-covalent-post-assembly-modification-cascade-self-assembled.html Depictions (same scale) of the X-ray crystal structures. a, Cube 1b. b, PF6 − adduct of tetrahedron 3. c, AsF6 − adduct of modified tetrahedron 4a. Atom colours: grey, C; white, H; red, O; blue, N; orange, Fe; light green, F. Disorder and non-encapsulated anions are omitted for clarity. Iron atoms are connected with orange lines to illustrate the overall geometry of each complex. Credit: (c) Nature Chemistry (2017). DOI: 10.1038/nchem.2839 Journal information: Nature Chemistry This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. 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It is said that one’s body is a temple, but how long can one live in the same house before redecorating it? Renowned actor Angelina Jolie said once that all her tattoos came at good times, adding that “a tattoo is something permanent when you’ve made a self-discovery, or something you’ve come to a conclusion about”. Tattoo art is an old art, with spiritual connotations in some tribal cultures of the belief to follow the bearer into the afterlife. Slowly but surely, tattoos are beginning to carve for themselves their own niche in the cultural fabric of society as an art form. Also Read – Add new books to your shelfAnd as author Sylvia Plath said, “a tattoo is like wearing one’s heart on one’s skin,” tattoo is now no longer just a tribal ritual but is turning into a fashion statement. The second Heartwork Tattoo Festival is being held in the national Capital at Indira Gandhi Indoor Stadium from the December 2 – 4 with the participation of around 110 artists in over 100 booths. The event will feature some of the best tattoo artistes from over ten countries. The event is being organized by the Czars of The Indian Tattoo Industry who formed a group called Creative Skin Graphic Pvt Ltd to revolutionise tattoo art all over India as they realised that getting inked was more than just a ritual. It was in the true sense Heart-work. Also Read – Over 2 hours screen time daily will make your kids impulsiveHeartwork is the brainchild of four pillars of the Indian tattoo industry: Lokesh Verma of Devil’z Tattooz, Delhi; Sameer Patange of Kraayonz Tattoo Studios, Mumbai; the biggest distributor of tattoo equipment in India, Anu Singh of Tattoo Empire, and Arvind Garg of Tattoo Gizmo. The opening performance will be by the renowned dancer/ choreographer/ actor Remo D’souza with a live tattoo on him. There will also be live workshops by legends of the International tattoo industry. They take upcoming artists through demonstrations on various art practices and design methods. Participating tattoo artists include Jay Freestyle from Netherlands, Bez 666 from the United Kingdom, Stepan Nagur from Russia, and Fred from Spain – all of whom have already achieved name and fame internationally. There will also be live Tattoo on-the-spot competitions on all the three days of the festival, with multiple categories to compete in. The best tattoos everyday will be eligible for trophies and prizes.On all the three days tattoo enthusiasts will witness entertaining and high energy acts of live music bands and Djs.The list of performers include Kabir Cafe, a fusion Sufi band, Jyoti Ram from France who does some crazy acts with his electronic sitar and crystal balls, and a standup comedian who is one of the best in the country.According to Sameer Patange, “Heartwork has come a long way and has been appreciated not just by tattoo artists but also by general masses in India as well as overseas. The idea of creating Heartwork was to create a general awareness amongst people and that has happened quite successfully. A huge lineup of foreign artists is going to make it to our shores this year. Let them see and know what we Indians are made of when we talk art”.Lokesh Verma added, “My basic idea to initiate Heartwork was to put Indian tattooing scene on the world map of tattoos. Looking at last year’s response and the number of international artists and media interested in this year’s event, I think we are on the right path. Let’s see where it takes us.” Arvind Garg said, “In the first year, Heartwork saw the biggest gathering of professional tattoo artists under one roof in India. With the first year’s success we can already see the tread moving from googling the tattoo design to the customised tattoo, we can see the personal stories in body art has seeped into popular culture. This indicates a dilution in the stigma that is usually associated with tattooing. With this effort Indian artist are able to showcase their skill which is seen at international level and now we can see that more and more Indian artists are being sponsored by international brands. “ Anu Singh Co-organiser expressed his thoughts about the celebrated tattoo festival, “We began our journey with Heartwork Tattoo Festival in 2015 to give Indian Artists a big platform to showcase their talent. And with the immense love and support of everyone it started a chain reaction. Carrying on the legacy we are back to give the best lineup of international and national performances in music, tattoos and art that everybody has been waiting for. We are pretty sure and excited that this year too its going to be one heck of a ride.”