Ex-Watford, Espanyol coach Sanchez Flores named coach of Shanghai Shenhuaby Paul Vegas10 months agoSend to a friendShare the loveFormer Watford and Espanyol manager Quique Sanchez Flores has been named coach of Chinese side Shanghai Shenhua.The Spaniard replaces Wu Jingui, who takes over as sporting director after steering Shenhua to victory in the Chinese FA Cup in 2017 Sanchez Flores has not worked since April, when he was dismissed by Spanish side Espanyol after almost two years at the helm.The former Real Madrid and Spain defender makes the move to China having also previously coached Watford in the Premier League, Benfica in Portugal and clubs in the United Arab Emirates. TagsTransfersAbout the authorPaul VegasShare the loveHave your say
Sagnol urges PSG to go for Liverpool midfielder Keitaby Paul Vegas9 months agoSend to a friendShare the loveFormer Bordeaux coach Willy Sagnol believes PSG should move for Liverpool midfielder Naby Keita.PSG are in the market for a new midfield signing as a replacement for wantaway Adrien Rabiot.And Sagnol says: “With (Marco) Verratti, you have a player who is very good technically, able to organise the game from deep. But he needs a player with a large volume of play at his side. “Naby Keita (Liverpool) is a player who knows how to do everything, who recovers balls, can also project with and without the ball. Verratti and Keita could form a beautiful duet if we assume that (Thomas) Tuchel retains his defence with three men behind.” TagsTransfersAbout the authorPaul VegasShare the loveHave your say
LSU landed its fifth commitment in the last five days Tuesday afternoon in three-star offensive tackle Shaahdiq Charles, who announced his decision on Twitter. With Charles’ pledge, the Tigers jumped Alabama and Miami on its way to the No. 3 recruiting class in the country – and No. 1 in the SEC – according to 247 Sports.LSU has always recruited well, so this momentum comes as no surprise. But the 2017 recruiting cycle is far from over. A lot can change before next February.
VICTORIA – Real estate experts say the British Columbia government started to build a strong foundation for more affordable housing in Tuesday’s budget, but opinion varies on the expected outcomes.Finance Minister Carole James is trying to ease the province’s housing crisis by introducing a new tax on property speculators, expanding and increasing a tax on foreign homebuyers and spending $6 billion to build affordable housing over the next decade.James said she expects to see property values start to drop as her budget measures kick in.“We’re an amazing province,” she said Wednesday after speaking to the Greater Victoria Chamber of Commerce. “There’s no question people are going to want to live in B.C. But we need to see a moderation and my hope is, by addressing both supply and demand, you’ll see more supply in the market that will ease some of the cost pressures and you’ll see a moderation.”Tom Davidoff of the University of British Columbia’s Sauder school of business said he hopes the speculation tax will help make the lower end of the market more affordable, particularly for condos.The levy will be introduced this fall, targeting foreign and domestic homeowners who do not pay income tax in B.C., including those who leave homes vacant.In the 2018 tax year, the rate will be $5 per $1,000 of a property’s assessed value. Next year, the rate will rise to $20 per $1,000 of assessed value. It will initially apply to Metro Vancouver, the Fraser Valley, the Victoria area, the Nanaimo Regional District, Kelowna and West Kelowna.A non-refundable income tax credit will also be introduced to offset the new levy, providing relief for people who do not qualify for an exemption but who pay income taxes in B.C.James said B.C. residents with multiple properties, such as a summer cottage, will get the levy back as a credit on their income tax refund. But property owners from out of province will be dinged if they leave their B.C. home vacant, she said.The tax makes a lot of economic sense, Davidoff said, because B.C. has high income and sales taxes but low property taxes, which encourages vacationers to buy property and makes life more expensive for workers.“That is the worst possible idea in a market like Vancouver where you have a tremendous amenity level and it’s so hard to build,” he said. “We’re such a draw for people who don’t want to work here, but do want a lovely vacation home.”People who are affected by the new levy might sell their properties, freeing up housing for locals, he said.One issue the budget didn’t directly address is zoning, Davidoff said, adding that the taxes on speculation and foreign buyers might provide some indirect help because they will “bash” the high end of the real estate market. That encourages people to push for changes in zoning density to keep their property values up, he explained.“The property they own is going to be worth a lot less than it was before this tax. When you have new zoning, there’s a trade off — your property becomes more valuable because you can put greater density on it, but you don’t like what’s happening to your neighbourhood,” Davidoff said.He said the changes make it more attractive for people to subdivide a single luxury property into five or six moderately priced properties.Cameron Muir, chief economist at the Real Estate Board of B.C., said plans to help build 114,000 affordable housing units will offer much needed supply for rental and low-income properties.But he said a tremendous undersupply of available homes in Metro Vancouver, Victoria and Kelowna, coupled with B.C.’s strong economy, will keep home prices from dropping.“In terms of market impacts, it may be great to raise tax revenue, but this is not going to have a demonstrable impact on housing markets,” said Muir. “The chief culprit of rising home prices is the inability to supply the housing market in a timely fashion.”The head of an association of real estate developers across B.C. said measures in the budget won’t bring down prices for non-subsidized housing.An additional property transfer tax on homes worth more than $3 million will make it more expensive for developers to acquire land and that cost will be passed on to buyers, said Anne McMullin, president and CEO of the Urban Development Institute.There also isn’t enough labour to build thousands of new affordable housing units while keeping pace with the demand for housing built at market prices, and unless the province works with municipalities to speed up approval times, home prices will remain high due to a lack of supply, she added.“You can’t say ‘I’m going to add all these below market and social housing (units) to the market place, to the labour pool, to the industry,’ without dealing with the supply side, without dealing with the long processing times, without dealing with the lack of competition in the marketplace,” McMullin said.— With files from Gemma Karstens-Smith in Vancouver.
LIMA, Peru – Thousands of miles from home, Vice-President Mike Pence was thrust into a new, more immediate, role on the world stage Saturday: explaining President Donald Trump’s military strike in Syria to a summit of Latin America leaders.Hours after Trump hailed the missile strike targeting the Syria’s suspected chemical weapons — tweeting, “Mission Accomplished!” — Pence defended the president while building support among U.S. allies for the joint strikes with Britain and France.“The objective of the mission the commander in chief gave our military forces and our allies was completely accomplished — with swift professionalism,” Pence told reporters, noting there were “no reported civilian casualties.”Later, speaking in a cavernous hall of world leaders at the Summit of the Americas, Pence expressed gratitude to Canada, Colombia and other nations that had voiced support for the strike and urged “every nation in this hemisphere of freedom” to support the military action.Pence’s to-do list included smoothing over differences with Mexico, America’s southern neighbour, amid unease over Trump’s decision to send troops to the border and harsh rhetoric on immigration. And with tensions simmering over trade, Pence expressed hope alongside Canadian Prime Minister Justin Trudeau that the three nations could soon agree to a renegotiated North American Free Trade Agreement.And while Trump grapples with the ongoing Russia investigation led by special counsel Robert Mueller, Pence sought to draw a bright line against Vladimir Putin’s alliance with Syria following the suspected chemical attack. “Our message to Russia is that you’re on the wrong side of history,” Pence said.Trump often improvises his remarks and is known for bold declarations in person and on his Twitter account. Pence, meanwhile, tends to be more scripted in his exchanges and frequently glanced down at highlighted index cards as he spoke to Latin American leaders here.Shortly before Trump’s address to the nation Friday night, Pence was whisked away from the summit in his motorcade so he could return to his hotel to inform congressional leaders of the pending missile strikes. Pence watched Trump’s speech from his hotel suite, joined by aides.Unlike past appearances at international summits, the vice-president had to dive into the packed agenda on short notice. He learned only Tuesday that he would be attending in Trump’s place so the president could manage the U.S. response to Syria.In meeting after meeting, Pence offered a low-key, extended hand.Seeking rapprochement with Mexico, which has been at odds with Trump over the border wall and immigration, Pence said the topic of funding for Trump’s long-promised border wall did not come up in his meeting with Mexican President Enrique Pena Nieto.Pence said they simply had a difference of opinion and some issues were “set aside, for a later date.” Left unsaid was whether Pence’s overtures might eventually lead to a joint Trump-Pena Nieto meeting, their first.Seated alongside Trudeau, Pence said there was a “real possibility” the U.S. could reach a deal with Canada and Mexico on NAFTA “within the next several weeks.” Trump has long assailed the trade deal’s impact on U.S. workers and threatened to pull the U.S. out if he’s unhappy with the terms.The summit also gave Pence an opportunity to press the case for tougher sanctions and more isolation of Venezuela across the region.Venezuelan President Nicolas Maduro was barred from attending the summit over his plans to hold a presidential election that the opposition is boycotting and that many foreign governments consider a sham.Pence urged Maduro to accept humanitarian aid as the once-prosperous nation deals with humanitarian and economic crises. But he called on the region to take a harder line on Maduro’s government, a message he intends to deliver in Brazil next month.“The United States believes now is the time to do more, much more,” he said.___On Twitter follow Ken Thomas at https://twitter.com/KThomasDC
“The museum is a gem of Tumbler Ridge. It’s something people from all over the world come to see.”Our calls for comment from the District of Tumbler Ridge have not been returned.The Peace Region Paleontology Research Center and Museum opened in 2003.The March 12, 2018, District of Taylor Committee Meeting included a presentation from the Tumbler Ridge Museum Foundation. “Our goal and our desire and hope is the museum will reopen. That we will find funding to provide the same amazing service to people and tourism possibilities.”The board decided in early March to let go all staff as current funding would only last them until the end of 2018 if they closed the museum.This letter was given to staff of the museum.Council and the Museum Board held a meeting on March 12 to discuss the grant-in-aid further, but as of now, the Museum remains closed.The board is now working to find alternative funding through grants or corporate donations. Schembri says the Museum is a big part of Tumbler Ridge. During the meeting, Councillor Will Howe said,“We had a roundtable discussion where all of them were allowed to come down and explain how this works. To me, that was the opportunity for the museum board to come down and explain to us why they need the two hundred thousand dollars. To me, until we get that done, I don’t fully understand it, and I’m not to spend the $200,000.”Here is video from the March 5, Council meeting where they discuss the grant-in-aid.In July of 2017, Councillor Caisley requested a notice of motion that said: “THAT the District of Tumbler Ridge informs the Tumbler Ridge Museum Foundation Council is suspending funding their institution through the Grant in Aid or Fee for Service Policy until conditions are met.”According to the Council on March 5, 2018, a letter was sent to the Museum Board in July 2017 asking for more information about their budget, and according to Council, the letter had not been answered.Jerrilyn Schembri, Vice President of the Tumbler Ridge Museum Foundation, says as far as she knows, the board has complied with everything Council has asked of them.Schembri says the Museum has been idled. TUMBLER RIDGE, B.C. – The Tumbler Ridge Museum Foundation, The Peace Region Palaeontology Research Centre and Dinosaur Discovery Gallery has been closed for what the group hopes is only a short period.In March, the District of Tumbler Ridge denied the groups request for a grant-in-aid of $200,000. On March 8, the Tumbler Ridge Museum Foundation gave notice to all the staff that the Museum would close do to the District of Tumbler Ridge denying their grant request.According to the video from March 5, 2018, Tumbler Ridge Council Meeting, Council had requested more information from the Museum Foundation, but the Museum at the time of the meeting had not replied.
Manchester United boss Jose Mourinho aimed a jibe at Premier League chief Richard Scudamore following his side’s 2-1 victory over Leicester CityCaptain Pogba converted from the spot inside the first five minutes while Luke Shaw netted his first goal for United to increase the lead for Mourinho’s men.However, Jamie Vardy’s goal in added time created a tense ending in what was an overall lackluster display from the Red Devils.Mourinho didn’t hide his emotions and wasted no time to lambast Scudamore over the Premier League schedule.“Mr Scudamore must be happy, it’s a good way to start the Premier League,” Mourinho told Sky Sports.Jose Mourinho is sold on Lampard succeeding ar Chelsea Tomás Pavel Ibarra Meda – September 14, 2019 Jose Mourinho wanted to give his two cents on Frank Lampard’s odds as the new Chelsea FC manager, he thinks he will succeed.There really…“A good match. A match where I needed six changes not three. I want to play Martial but I can’t, Paul Pogba can’t play 90, Fred the same. I need more changes.“It was not easy to manage the game from the touchline. But I told the players we had good periods, lots of glimpses of the type of football we wanted to play. Leicester were strong in periods but we coped with that as a team.“The team played as a team. In the second half, I had Andreas Pereira and Fred with a yellow card, Paul was fantastic his contribution was amazing but the fuel was disappearing. We were in trouble.“Martial in the last 20 minutes could have given us the second goal but I couldn’t make that change. The players gave everything, they gave what they had. Everybody did that.”
Related Items: Facebook Twitter Google+LinkedInPinterestWhatsApp#TurksandCaicos, September 6, 2017 – Providenciales – It is certain now that parts of the Turks and Caicos Islands will get a direct hit from Hurricane Irma scheduled to impact overnight on Thursday. I encourage all the residents and visitors of these islands to seriously prepare. Do not take this hurricane likely – it is an unprecedentedly dangerous – a strong Category 5 hurricane with wind speeds up to 185mph and tide surge potentially up to 30 feet. Please listen for weather advisories and heed the advice given by authorities.Residents of Salt Cay, and Middle Caicos I encourage you to take the advice of authorities in your area for evacuations, and those living in coastal areas should either move inland or to high floors.Ensure that your home is properly secured and your surroundings are cleared of any possible debris. Those in flood prone areas are especially advised to take heed in securing your property. Please make use of the Hurricane Shelters if you need to and have all that you may need at the shelter including food, clothing, toiletries, blankets, important documents, etc. Be sure that you have enough food and drinking water for each member of your family to last at least a day or two after the storm, as electricity may not return immediately. Fully charge all of your electronic devices including your additional/backup batteries. Check to ensure your flash lights and lanterns are working and have spear batteries on hand. Remember to protect all of your important documents in water-proof containers.Keep battery powered radios with you and listen for advisories/updates, as they become available.We are a resilient people and will make it through and I pray for God’s protection over us during this storm.Press Release: Washington Misick (Leader of Opposition) Facebook Twitter Google+LinkedInPinterestWhatsApp
Facebook0TwitterEmailPrintFriendly分享The Alaska State Senate is expected to bring forward a bill dealing with Alaska Permanent Fund dividends. The bill is expected to be introduced Monday and scheduled for an initial hearing. Governor Mike Dunleavy is adamant that a longstanding dividend calculation should be followed. Others say the formula is outdated and unsustainable. Governor Dunleavy held a Facebook Live Town Hall on Friday to discuss a variety of issues and topics relating to the ongoing Special Session. The topics included the lack of progress on a number of outstanding items such as the budget, education funding and a full PFD. Governor Dunleavy: “The operating budget, PFD, the crime bill is out of the way, and there is discussion on the capital budget as well. We are hoping that the Legislature can come to terms amongst themselves on these very important items soon. Then we can get moving onto talk many other issues that we ask Alaskans have to tackle.” Senate President Cathy Giessel said last week she couldn’t say what the final amount settled on would be, since bills are subject to amendment on the Senate floor. The House and Senate have remained divided on how to deal with the dividend which resulted in the need for a special session. Now halfway through and a resolution still has not been reached between the two bodies.
Barney Feinberg is the President of the Kay Group – Life Balance Recruiters. He is a Certified Life Coach who has merged Life Coaching with Executive Placement. He can be reached at firstname.lastname@example.org. You walk into work on Friday, getting ready for the weekend with your family. Sitting down at your desk you start your day, checking e-mail messages as you drink your coffee, milk no sugar.It is 9:15 in the morning when you get a call from the director of human resources to come into her office. A bell goes off in your head but you choose not to notice it. As you walk into her office you notice your boss on the other side of the desk. As you sit down in your chair you feel as if you are sinking and there is an unfamiliar anxiety covering you like a hot beach blanket, causing you to sweat. Then the words, “Today is going to be your last day….You have just been downsized.There is an initial shock, grasping for more to understand, as if there was a way to change the decision. An offer is made for severance after you sign some papers. You are then escorted to your desk to take your personal belongings; feeling like you were walking the last mile to oblivion with eyes staring at you, some comforted that it is not them, others wondering who’s next.You have been stripped of your perceived security, sent into the street with little to show for it and the uneasy realization that the mortgage payments never stop, your eldest son needs braces, and what are you going to tell your spouse who works part time without benefits? Is the Iceberg Melting?The most important thing to accomplish after being downsized is to realize your fear and understand that you can either use it as an asset or it will use you, causing a paralysis of action. For most of us, it is something to get rid of, an uncomfortable anxiety. We may succeed at times but it doesn’t just go away, it is something that can come back many times with many things triggering it, including my introduction to this article. It can take away our confidence and make us settle for less than we can achieve to live our dreams for a wonderful life.We can be great creators of fear, often projecting worst case scenarios that never happen. I work in the Empire State Building and after 9/11 I can tell you it was easy to create fear, worrying about future events. Worry is planning for failure and anyone in a successful business will tell you it is better to plan for success.Planning for success in the face of the unknown is where you want to be when finding your next career opportunity. You may be thinking, “That makes sense, but easier said than done, I have all these things to worry about.” When one is downsized it can be easy to worry, especially if you have a lot of financial responsibilities to meet. I am here to tell you planning for success takes your mind off of worry and with practice it becomes easier.How can we use fear as an asset? Speak to actors with stage fright; many rely on that energy from increased adrenaline to enhance the passion of their performance. They focus their attention on the actions they intuitively know they can perform, brilliantly!If you have recently been downsized, just noticing that you are worrying and planning for failure can help you choose to get back into planning for success. Success planning is a very powerful place to be that will lead you to action in finding your next career move.For those of you who are reading this article and working, yet understand that some day downsizing could happen to you, a friend, or family member, this is the perfect time to plan for success.This planning can be done every day and not just for your career but for every area of your life. It can be a short range plan that you can take action on immediately, such as going to the gym or getting to bed on time. It can be a long range plan that has milestones of accomplishment before you reach your goal such as losing 10 lbs. over a period of time or creating a Web site. The key is to make success planning a habit in every area of your life.There are many ways to find a new job: networking, job boards, direct company contact, and executive recruiters. Being in action by planning for success will bring the results you want much quicker with less stress. Deal with downsizing from strength not fear.
State-owned telecom operators – Bharat Sanchar Nigam Ltd (BSNL) and Mahanagar Telephone Nigam Ltd (MTNL) – are reportedly in talks with private players to share spectrum in a bid to reduce losses and improve their revenues.”We are talking to two-three private operators. We have unutilised spectrum in many locations, in different circles,” a senior BSNL official told Business Standard.While MTNL provides telecom services in Delhi and Mumbai, BSNL offers services in the rest of the country. Due to intense competition in the telecom space, both the public sector operators have been struggling, incurring huge losses for the past few years.BSNL had posted a loss of Rs 7,600 crore for the financial year ending 31st March 2015, while MTNL’s loss stood at Rs 745 crore in the first quarter of the current financial year.Sharing spectrum with the two government-owned telcos is expected to assist private operators to address rising call drop issues. It will enable them to use their spectrum efficiently.In a bid to address the growing furore over increasing call drops, the telecom regulator has recently recommended operators to provide compensation to users for each dropped call. The Telecom Regulatory Authority of India (TRAI) has asked the operators to offer a compensation of Re 1 for each call drop.With the government giving its green signal for spectrum sharing, many companies have intensified their talks for such an arrangement, said the BSNL official.Nevertheless, the government has to ease the spectrum cap limits in order to enable spectrum sharing between two major telecom operators.As per the existing rules, an operator is not permitted to have over 25% of the spectrum allotted to all operators “in a particular circle or more than 50% of spectrum assigned in a particular frequency band.”
High-CourtThe High Court on Tuesday withdrew a stay order and asked the subordinate court to complete trial proceedings in a corruption case against Bangladesh Nationalist Party (BNP) leader Shahid Uddin Chowdhury Annie, reports UNB.The bench of justices Md Nazrul Islam Talukder and KM Hafizul Ala rejected a plea that sought cancellation of the Anti-Corruption Commission (ACC) case.Advocate Md Khurshid Alam Khan stood for ACC while deputy attorney general AKM Amin Uddin Manik represented the state and advocate Jainul Abedin stood for Annie.ACC deputy director M Manjur Murshed filed the case with Ramna police on 9 October 2014.The former MP was accused of concealing information about Tk 13,13,940 in a financial statement filed at the ACC and having Tk 1,40,42,670 in undisclosed property.Dhaka Special Judge Court framed charges against Annie on 24 May 2016. On 1 September that year, the High Court stayed the trial proceedings for six months and issued a rule asking why the applicant should not be acquitted.
Live Stats With 33 points at Western Kentucky, 24 at Chattanooga, 20 at Boise State and 20 vs. Hartford, Durr has nine career 30-point games and 41 career 20-point games. Kylee Shook is tied for third on the team with 8.5 points per game, while shooting 6-12 (.500) from downtown and pulling down 4.0 rebounds. She also leads the team with six blocks. She scored a season-high and team-high 17 points, 6-9 from the floor and 1-3 from 3-pt range, while adding a season-high six rebounds, including five offensive boards, in the win over Miami (Ohio).Head coach Jeff Walz was an assistant at Nebraska from 1997 to 2001. This will mark the second time that he has faced his former team. The Cards downed the Cornhuskers 65-51 on Dec. 20, 2010 in Las Vegas. Tickets Media Center Watch Last season, the ACC went 10-4 in the ACC/Big Ten Challenge. The ACC is 8-0-3 in the challenge. UofL is 3-1 in the ACC/B1G Challenge. 2017 – Louisville 72, Indiana 59 (at IU); 2016 – Maryland 78, Louisville 72 (at UL); 2015 – Louisville 85, Michigan State 78 (at MSU); 2014 – Louisville 86, Iowa 52 (at UL) The Cardinals are off to a 6-0 start, which marks the third straight season that they have started at least 6-0. They started off 6-0 in 2016-17 and a school-record 20-0 in 2017-18. Dana Evans is tied for third on the team with 8.5 points per game and is averaging a team-high 5.5 assists. After starting the first two games, she has come off the bench the last four. In the last three games, she is averaging 12.0 points and has 18 assists to just four turnovers. She has led the team in assists in four of six games. She had a season-high 14 points and a team-high six assists vs. Miami. She had 11 points and six assists, including the game-winning dish to Sam Fuehring with 2.5 seconds to go vs. ASU. She scored eight of her 11 points in the fourth quarter. She then had 11 points and a team-high six assists and three steals vs. Hartford. She recorded nine assists at UTC, which was one shy of her career-high of 10 at Kentucky (12/17/17). Louisville recorded a season-high 16 steals in the 95-73 win over Miami (Ohio). It marked the most steals in a game since they had 16 vs. Bowling Green (W, 83-58) and Lafayette (W, 92-48) in back-to-back games on Nov. 19 and Nov. 20, 2016. Last year, they had a season-high 15 steals vs. Murray State (W, 115-51) on Nov. 24, 2017. The Cards are averaging 10 steals per game and have had at least seven in every game. Asia Durr had two 3-pointers (2-6) in the win over Miami, giving her an even 300 3-pointers for her career. She is only the second player in program history with 300 3-pointers. She ranks second behind Shoni Schimmel, who has 387 career 3-pointers. As a sophomore, she connected on 119 3-pointers, which ranked second nationally and set school record. She had 115 3-pointers last season. Story Links Listen Bionca Dunham has started the last four games after getting her first career start vs. Boise State on 11/19. On the season, she is averaging 7.8 points, while shooting 19-29 (.655) from the floor, and pulling down 3.2 rebounds. Against Miami (Ohio), she finished with a season-high 15 points on 7-10 shooting, while adding a team-high and career-high four steals. LOUISVILLE, Ky. – After downing Miami (Ohio) in the home opener, University of Louisville women’s basketball continues its six-game homestand when they host Nebraska in the ACC/Big Ten Challenge on Thursday night at 7 p.m. ET. Prior to the game, Louisville’s 2018 NCAA Final Four Banner will be unveiled.ABOUT THE CORNHUSKERSLast season, Nebraska finished the season with a 22-11 overall record, 11-5 in the Big Ten, and advanced to the NCAA Tournament, falling to No. 7 seed Arizona State, 73-62 in the first round. They return four starters from that team and have opened the season with a 2-3 record. Their three losses are to Drake, 83-77, at Washington State in double overtime, 87-84, and at No. 21 Miami, 82-68. Their wins have come against USC Upstate, 87-64, and Radford, 77-39. They have eight players averaging more than 7.2 points per game. Freshman guard Sam Haiby leads them in scoring with 11.4 points per game, while sophomore guard Taylor Kissinger is second with 9.6 points per game and ranks second in the nation in 3-point shooting percentage at 66.7 (12-18). Series History – Louisville is 2-1 all-time against the Cornhuskers and 1-0 at home. This will mark the first matchup between the two teams since that matchup in Las Vegas. They met twice in non-conference play in 1998-99 when Walz was an assistant at Nebraska. The Huskers defeated Louisville 62-61 at the Rainbow Wahine Classic on Nov. 29, 1998. Louisville then knocked off the Huskers 77-66 at the Seelbach Holiday Classic at Freedom Hall on Dec. 29, 1998.Date: Thursday, Nov. 29Time: 7:00 p.m. ETSite: KFC Yum! Center Louisville, Ky. (22,000)Radio: WKRD-790, Nick Curran, play-by-play; Adrienne Johnson, analystVideo: ACCNE, Don Russell, play-by-play; Sara White, analystLast Meeting: W, 65-51 (Dec. 20, 2010 in Las Vegas)Series History: 2-1 (1-0 Home, 0-2 Away, 1-1 Neutral)UofL National Ranking: 5th Associated Press, 4th USA TodayOfficials: Dee Kantner, Eric Brewton, Mark ReschFor the latest on Louisville women’s basketball, visit GoCards.com, follow the team’s Twitter account at @UofLWBB or on Facebook at facebook.com/UofLWBB. Print Friendly Version
© 2017 Phys.org Explore further Inspired by natural signaling cascades, chemists have developed synthetic cascades that modify a self-assembled supramolecular structures post-assembly. Researchers from the University of Cambridge have developed a synthetic cascade that is triggered by norbornadiene (NBD) and relayed by a cyclopentadiene (CPD) intermediate resulting in the triggered change of two supramolecular structures. Their work appears in Nature Chemistry.After a one-pot self-assembly of two supramolecular structures, the Nitschke group developed a post-assembly modification (PAM) technique via a covalent signal cascade. PAM reactions are limited by the need to be sufficiently mild that they do not damage the supramolecular structure. They also need to be chemoselective and produce product in near-quantitative yields to eliminate the need for extensive purification and isolation. Diels-Alder reactions are good candidates for these types of reactions.Pilgram, et al. developed a system that underwent inverse-electron demand Diels-Alder (IEDDA) reaction with the initial triggering molecule, NBD, and a tetrazine-edged FeII8L12 cube, and subsequent Diels-Alder reaction with the relay molecule, CPD, and a tetrahedral complex. Their studies verified that the reactions required the triggering molecule and the relay molecule in order to work.Specifically, the synthetic scheme involved first making the terazine-edged cube in a one-pot synthesis. It then underwent the IEDDA reaction between the tetrazines and the NBD trigger molecule. After conducting model reaction tests, they used 2-octadecylnorbornadiene giving a pyridizine-edged cube and a 1-octadecylcyclopentadiene intermediate. This intermediate served as a relay molecule that bound to the maleimides on the tetrahedral complex via a Diels-Alder reaction.In one test, the final reaction involved forming a CPD intermediates with sufficiently long alkyl chains that the tetrahedral product transfers from an organic polar phase to a non-polar phase. Notably, without the initial triggering molecule, the final product is not formed and does not move into the non-polar phase, thus demonstrating a synthetic signal cascade in which a molecule changes lipophilicity as a result of an environmental trigger.Additionally, because the cell’s signal transduction pathways are often regulated by both triggering species as well as inhibitors, the Nitschke group investigated potential inhibitor molecules to their synthetic cascade. They found that cyclooctyne served as a good inhibitor by competitively reacting with the terazine molecules over the NBD trigger.Finally, another key finding of their synthetic cascade is that when the tetrahedral structure is complexed with an anionic guest (PF6-), the guest remains intact even after post-assembly modification of the structure. This allows the guest molecule to be transported from the polar to non-polar phase, which has implications for medicinal and other applications where molecule delivery is hindered by polarity or other environmental features.Dr. Nitschke told PhysOrg that future research includes designing cascades of reactions that are capable of being pushed backwards under out-of-equilibrium conditions. According to Nitschke, “Cascades of out-of-equilibrium reactions that are geared together such that one sequence of reactions either up-regulates or down-regulates another are fundamental building blocks of life. Understanding how they might work could help us understand prebiotic chemistry, as well as help us design complex synthetic assembly lines where substrates are passed along between capsules that chemically modify them.” More information: Ben S. Pilgrim et al. Signal transduction in a covalent post-assembly modification cascade, Nature Chemistry (2017). DOI: 10.1038/nchem.2839AbstractNatural reaction cascades control the movement of biomolecules between cellular compartments. Inspired by these systems, we report a synthetic reaction cascade employing post-assembly modification reactions to direct the partitioning of supramolecular complexes between phases. The system is composed of a self-assembled tetrazine-edged FeII8L12 cube and a maleimide-functionalized FeII4L6 tetrahedron. Norbornadiene (NBD) functions as the stimulus that triggers the cascade, beginning with the inverse-electron-demand Diels–Alder reaction of NBD with the tetrazine moieties of the cube. This reaction generates cyclopentadiene as a transient by-product, acting as a relay signal that subsequently undergoes a Diels–Alder reaction with the maleimide-functionalized tetrahedron. Cyclooctyne can selectively inhibit the cascade by outcompeting NBD as the initial trigger. Initiating the cascade with 2-octadecyl NBD leads to selective alkylation of the tetrahedron upon cascade completion. The increased lipophilicity of the C18-tagged tetrahedron drives this complex into a non-polar phase, allowing its isolation from the initially inseparable mixture of complexes. (Phys.org)—Within the cell chemical messages are passed through a signaling cascade. This cascade can be a series of chemical reactions or molecular changes that spurn the next reaction in a kind of assembly line process. This is how the cell responds to its environment and how communication happens over (biochemically ) long distances. Chemists build new chemical structures on unreactive bonds Citation: Covalent post-assembly modification cascade of self-assembled supramolecular structures (2017, September 6) retrieved 18 August 2019 from https://phys.org/news/2017-09-covalent-post-assembly-modification-cascade-self-assembled.html Depictions (same scale) of the X-ray crystal structures. a, Cube 1b. b, PF6 − adduct of tetrahedron 3. c, AsF6 − adduct of modified tetrahedron 4a. Atom colours: grey, C; white, H; red, O; blue, N; orange, Fe; light green, F. Disorder and non-encapsulated anions are omitted for clarity. Iron atoms are connected with orange lines to illustrate the overall geometry of each complex. Credit: (c) Nature Chemistry (2017). DOI: 10.1038/nchem.2839 Journal information: Nature Chemistry This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. 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Art is a strong medium to showcase what’s going on in an artist’s mind and nothing better than art can bring out their imagination on canvas for others to see and feel what the artist felt while making it. An exhibition of paintings titled ‘Mamtamayi’ will be held from February 13-19 in the national Capital. Spreading the message of mother’s love and care, the exhibition will showcase works by Harshvardhan Arya.Artist Harshvardhan is one of those artists who try to portray the work that touch the soul and provides a strong message. Also Read – ‘Playing Jojo was emotionally exhausting’His works mostly talk about the preservation of environment. Motherly love is highly reflected in his paintings. In some of the paintings true love can be seen via Lord Krishna’s child avatar while some provide a message about a daughter’s safety. In the upcoming exhibition, an art lover can see the depiction of a loving mother and her care being expressed with very deep intensity on canvas by the artist.When: February 13-19 Where: Lalit Kala Akademi Timing: 11 AM to 7 PM